Cheap flights from Medellin to Santiago

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Find the cheapest month or even day of the year to fly to Santiago

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Flight deals from Medellin to Santiago

Looking for a cheap last-minute deal or the best round-trip flight from Medellin to Santiago? Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from Medellin to Santiago

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Medellin to Santiago flights are currently cheapest in March.

Medellin to Santiago: Alternative routes

Compare routes from Medellin to Santiago below. You may find an airport to fly into that's cheaper, faster, or easier than Santiago.

Medellin to Santiago: Flight information

The things to know before you go.
Cheapest flight found$397
Cheapest month to flyMarch

Finding cheap flights from Medellin to Santiago: Frequently asked questions

The best price we found for a round-trip flight from Medellin to Santiago is $397. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Medellin to Santiago. But we found flights with one stop from $397.
There are no flights flying from Medellin to Santiago, as of February 2026.
The cheapest month to fly from Medellin to Santiago is usually March.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Medellin to Santiago Airport on Saturday, March 7, 2026.
No airlines currently offer direct flights between Medellin and Santiago Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santiago but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Santiago is around 40 days in advance, so don’t leave your flight to the last minute.
The cheapest airline that flies to Santiago is Copa.

Flying from Medellin to Cibao International Airport (STI): What you need to know

  • Jose Maria Cordova International Airport (MDE) is Medellin's main airport. Explore your options for booking a flight from Medellin to Cibao International Airport (STI) leaving from here.

  • Cibao International Airport is located in Santiago. The city follows the UTC-4 timezone and is one hour ahead of Medellin.

  • To ensure you get on your flight from Medellin to STI, allow plenty of time to navigate the airport and find your gate. Arriving two hours before international departures and an hour before domestic flights is the general travel rule.

  • During peak travel periods, expect longer wait times and arrive earlier. Aim for at least two hours ahead for domestic flights and as much as four hours for international trips.

Airports in Medellin

Jose Maria Cordova International Airport (MDE)

  • We make it simple to book cheap flights from Medellin to STI with a stopover. To explore all the options leaving from Jose Maria Cordova International Airport (MDE), uncheck 'Direct flights only.' Then, choose a flight that has a stop long enough to tour your chosen city. Top stopovers between MDE and STI include:

    • Tocumen International Airport (PTY)

    • Luis Munoz Marin International Airport (SJU)

    • Las Americas International Airport (SDQ)

  • MDE is around 24 kilometers from central Medellin. If you're ride-sharing, catching a cab or driving from the center, it'll take 35 minutes or so to get there, depending on the traffic.

  • Want a relaxed start to your travels? Stay near Jose Maria Cordova International Airport. Whether you've booked an early flight from Medellin to Cibao International Airport or prefer not to rush, these hotels have you covered:

  • Of the flights that depart from Jose Maria Cordova International Airport, 69.76% touch down on time at their destination.

Enrique Olaya Herrera Airport (EOH)

  • On public transport, you can travel from central Medellin to EOH in around 30 minutes. The terminal is roughly 6 kilometers away, and making the journey by car will take approximately 15 minutes.

  • Get a head start on your vacation with an additional night away from home. Before catching your Medellin to STI flight, stay in one of these hotels close to Enrique Olaya Herrera Airport:

About Cibao International Airport (STI)

Getting from Cibao International Airport (STI) to central Santiago

  • Cibao International Airport to the center of Santiago is roughly 13 kilometers. If you're renting a car or taking a cab, do a little research to make your trip as easy as possible. Journey times may vary based on the time of day and traffic conditions.

  • It takes around 1 hour 10 minutes to get there using public transport.

How to find the cheapest flights from Medellin to Cibao International Airport (STI)

  • Right now, $246 is the lowest price we've found for a one-way ticket from Medellin to Cibao International Airport. The cheapest price for a return flight is $397. Keep in mind fares may change due to demand at the time of booking.

  • Don't wait until the last moment. You're more likely to find cheap flights from Medellin to STI if you book ahead. Airlines often have some great early bird rates.

  • The 'Whole month' search tool will show you the cheapest Medellin to Cibao International Airport tickets across every month. It's a good way to find a bargain if your trip dates are flexible.

  • Spend less time searching for cheap plane tickets from Medellin to STI by setting up a Price Alert. We'll send you an email or notification through the app when a lower fare pops up.

  • Tailor your trip using filters. Pick your departure and arrival times, airlines and total journey duration. You can also sort your results by 'Best,' 'Cheapest' or 'Fastest' flights from Medellin to Cibao International Airport.

The best time to fly from Medellin to Cibao International Airport (STI)

  • Picture the kind of break you want when deciding your trip dates. May is the quietest month to go to Santiago. August is when most people book flights from Medellin to Cibao International Airport (STI), which may be perfect if you're after more action.

  • The warmest month in Santiago is August, with temperatures ranging between 21ºC (70ºF) and 33ºC (91ºF). Book your Medellin to STI plane ticket then if you enjoy this type of weather.

  • If you like cooler conditions, look for a cheap ticket from Medellin to Cibao International Airport in January when temperatures are between 16ºC (61ºF) and 29ºC (84ºF).

More about Santiago

  • Start your Santiago trip right by choosing the ideal place to stay. Once you've booked your flight from Medellin to Cibao International Airport, explore our range of hotels including:

  • Every great vacation has to include some sightseeing. MTB National Park, Catedral de Santiago Apostol and Baracoa Park are essential stops on your Santiago itinerary.

Explore more of the Dominican Republic

  • Santo Domingo is just one of the many cities in the Dominican Republic waiting to be discovered once you've seen Santiago. Around 129 kilometers away to the south-east, popular attractions include Alcazar de Colon, The Cathedral of the Americas and República Dominicana - Santo Domingod.

  • If there's time to check out another great destination in the Dominican Republic, head for Santo Domingo Este, roughly 129 kilometers south-east of Santiago. Lago los tres ojos, Los Corales Park and National Aquarium are among its highlights.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.