Cheap flights from Knoxville to Los Angeles

Compare Knoxville to Los Angeles flight deals

Find the cheapest month or even day of the year to fly to Los Angeles

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Flight deals from Knoxville to Los Angeles

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Los Angeles? Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from Knoxville to Los Angeles

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Los Angeles flights are currently cheapest in April.

Knoxville to Los Angeles: Flight information

The things to know before you go.
Cheapest flight found$244
Cheapest month to flyApril

Finding cheap flights from Knoxville to Los Angeles: Frequently asked questions

There are 7 airports in Los Angeles: Hawthorne, Burbank, Los Angeles International, Long Beach Municipal, Los Angeles Van Nuys, Santa Ana John Wayne, and Ontario International.
The best price we found for a round-trip flight from Knoxville to Los Angeles is $245. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Knoxville to Los Angeles. But we found flights with one or more stops from $245.
There are no flights flying from Knoxville to Los Angeles, as of February 2026.
The cheapest month to fly from Knoxville to Los Angeles is usually April.
If you're flying from Knoxville Airport, the cheapest airport near Los Angeles is Los Angeles International – which is 19.6 km away from the center of Los Angeles. We've found flights to this airport from $245.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Los Angeles on Thursday, April 16, 2026.
No airlines currently offer direct flights between Knoxville Airport and Los Angeles. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Los Angeles but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Los Angeles is around 40 days in advance, so don’t leave your flight to the last minute.
In February, the average temperature is usually around 12°C. August is typically the warmest month in Los Angeles, when it usually averages around 30°C. You can expect the least rain in August. The coldest month is December, with temperatures averaging 7°C. The rainiest month is February.
Currently, Frontier Airlines offers the cheapest flight tickets to Los Angeles.

Traveling from McGhee Tyson Airport (TYS) to Los Angeles: what you need to know

  • The timezone in Los Angeles is UTC-7. The city is three hours behind Knoxville, where McGhee Tyson Airport is located.

  • Give yourself enough time to catch your TYS to Los Angeles flight. It's generally best to arrive at least two hours before international departures and an hour ahead for domestic flights.

  • Taking off during a peak period like school or public holidays? Expect longer queues at check-in and security. Give yourself extra leeway and arrive up to four hours before international flights and two hours before domestic departures.

  • TYS is around 18 kilometers from central Knoxville. If you're ride-sharing, catching a cab or driving from the center, it'll take 20 minutes or so to get there, depending on the traffic.

  • Want a stress-free start to your vacation? Stay near TYS. Whether you're taking an early flight from McGhee Tyson Airport to Los Angeles or want to avoid feeling rushed, these hotels have you covered:

  • Of all flights leaving McGhee Tyson Airport, 78.98% land on schedule at their destination.

  • You'll find TYS at 2055 Alcoa Highway.

How to find the cheapest flights from McGhee Tyson Airport (TYS) to Los Angeles

  • The best price we've found for a one-way McGhee Tyson Airport to Los Angeles flight is $101. The cheapest price for a return flight is $244. Keep in mind fares can change due to availability at the time of booking.

  • Booking ahead of time is often the key to locking in a cheap flight from TYS to Los Angeles. Flight prices rise as demand increases, so the closer you get to departure, the more it could cost you.

  • Landing cheap tickets from McGhee Tyson Airport to Los Angeles is more likely if you can be flexible with your travel dates. Use the 'Whole month' search function to get the best prices throughout the month and land a fantastic deal.

  • Save time looking for cheap flights from TYS to Los Angeles by setting up a Price Alert. We'll send you an email or notification on the app when a lower fare becomes available.

  • Tailor your trip with filters. Pick your arrival and departure times, total journey duration and airlines. You can also sort the results by 'Best,' 'Cheapest' or 'Fastest' flights from McGhee Tyson Airport to Los Angeles.

Airports in Los Angeles

Los Angeles International Airport (LAX)

  • Los Angeles International Airport (LAX) is around 32 kilometers from the center of Los Angeles. If you're getting a cab or a ride-share, the drive takes about 30 minutes.

  • Getting there by public transport typically takes 55 minutes.

  • Think about booking a hotel near LAX if you have a late flight from McGhee Tyson Airport to Los Angeles. Select one of these accommodation options and make your first night all about rest:

  • Get your adventure underway by picking up a Los Angeles International Airport rental car. Grab your wheels from Dollar, Thrifty or Hertz and experience the lesser-explored corners of Los Angeles and beyond.

  • Booking your ride from Los Angeles International Airport around one week in advance of your flight from TYS to Los Angeles can help you get the best possible rate.

  • You'll find LAX at One World Way.

Van Nuys Airport (VNY)

  • The center of Los Angeles is around 32 kilometers from Van Nuys Airport (VNY). Once your flight from McGhee Tyson Airport to Los Angeles has hit the runway and you've navigated your way to arrivals, expect a drive of around 35 minutes.

  • If you choose to travel on public transport, you'll get to the city center in 1 hour 40 minutes or so.

  • Following your TYS to Los Angeles flight, kick back at a hotel near VNY. These are some comfortable options that'll help you slip into relaxation mode:

  • Forget about public transport schedules or slow-moving cab lines. Grab a Van Nuys Airport rental car and go in any direction that inspires you. Compare availability and rates from Budget, Dollar and Hertz.

  • Get your preferred vehicle, not just what's left over, by reserving your ride from VNY before your arrival. You'll also avoid paying more than you need to, especially during peak travel times.

Best time to go to Los Angeles

  • Carefully consider your dates before locking in your flight from McGhee Tyson Airport to Los Angeles. The city buzzes in peak season, but hotel rates are generally higher and attractions can get busy. Visit Los Angeles in the off-season for a quieter vibe.

  • Book a McGhee Tyson Airport to Los Angeles flight ticket with a departure in August if you want to explore the city during its warmest month. You can expect temperatures to range from 16ºC (61ºF) to 32ºC (90ºF).

  • If you want cooler conditions, look for a cheap ticket from TYS to Los Angeles in February when temperatures average between 6ºC (43ºF) and 26ºC (79ºF).

More about Los Angeles

  • Start your Los Angeles trip right by choosing the ideal place to stay. After booking your flight from McGhee Tyson Airport to Los Angeles, explore our selection of accommodation options including:

  • There are so many things to explore in this city it can be tricky to know where to begin. The Broad, Griffith Observatory and La Brea Tar Pits & Museum are top attractions which should feature on any well-planned Los Angeles itinerary.

Explore more of United States

  • You've done Los Angeles, now it's time to discover other corners of United States. Travel about 177 kilometers south-east to San Diego to check off its must-visit sights. From San Diego Zoo to USS Midway Museum and SeaWorld San Diego, you'll have a packed itinerary ahead.

  • Around 499 kilometers north-west of Los Angeles, San Jose is another favorite stop in United States. Experience this destination's highlights firsthand at Winchester Mystery House, Rosicrucian Egyptian Museum and San Jose Museum of Art.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.