Cheap flights from Guayaquil to Panama City

Compare Guayaquil to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from Guayaquil to Panama City

Looking for a cheap last-minute deal or the best round-trip flight from Guayaquil to Panama City? Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from Guayaquil to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Guayaquil to Panama City flights are currently cheapest in December.

Direct flights from Guayaquil to Panama City

Alternative Guayaquil to Panama City routes

Looking for the cheapest, fastest or easiest route from Guayaquil to Panama City? You could fly into the following airports instead.

Guayaquil to Panama City: Flight information

The things to know before you go.
Cheapest flight found$315
Cheapest month to flyDecember
Average flight time2 hrs, 11 mins
Most popular airlineCopa
Average flights per week123

Finding cheap flights from Guayaquil to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a round-trip flight from Guayaquil to Panama City is $315. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 11 minutes is the average flight time from Guayaquil to Panama City.
Copa, KLM and United fly direct from Guayaquil to Panama City.
There are 123 flights per week flying from Guayaquil to Panama City, as of December 2025.
The cheapest month to fly from Guayaquil to Panama City is usually December.
If you're flying from Guayaquil Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the center of Panama City. We've found flights to this airport from $315.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Guayaquil Airport to Panama City on Thursday, December 11, 2025.
Yes – the average flight time is 2 hours and 11 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In December, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, Avianca and Copa offer the cheapest flight tickets to Panama City.

Traveling from Jose Joaquin de Olmedo Airport (GYE) to Panama City: what you need to know

  • The average time for a direct flight from Jose Joaquin de Olmedo Airport to Panama City is 2 hours 15 minutes.

  • Panama City's timezone is UTC-5, which is the same as Guayaquil (the location of Jose Joaquin de Olmedo Airport).

  • With 36 weekly flights between the two airports, Jose Joaquin de Olmedo Airport (GYE) to Tocumen International Airport (PTY) is the busiest route. Copa Airlines operates the earliest flight at 04:26. If you prefer to make the most of your day before taking off, the last flight from GYE to PTY is with Copa Airlines at 18:49.

  • Give yourself enough time to get on your GYE to Panama City flight. It's generally best to arrive two hours before international departures and an hour ahead for domestic flights.

  • If you're jetting off during a major holiday or another peak period, give yourself more time. A good general rule is two hours before domestic flights and up to four hours before international departures. Queues at security and check-in will be longer.

  • Direct Jose Joaquin de Olmedo Airport to Panama City tickets are available for booking. Tocumen International Airport (PTY) is where you'll complete your journey.

  • Book your ticket with Copa Airlines. This popular carrier operates direct flights from Jose Joaquin de Olmedo Airport to Panama City.

  • Consider adding a stopover to potentially unlock a cheaper flight ticket from GYE to Panama City. Simply uncheck 'Direct flights only' during your search. Take a break (and maybe save some cash) by stopping at one of these airports:

    • El Dorado International Airport (BOG)

    • Jorge Chavez International Airport (LIM)

    • Mariscal Sucre International Airport (UIO)

  • GYE is about 5 kilometers from central Guayaquil. If you're catching a cab, ride-sharing or driving from the center, it'll take 10 minutes or so to get there, depending on the traffic. If you're using public transport, expect the journey time to be around 20 minutes.

  • Looking for a hotel near GYE? If you've booked an early flight from Jose Joaquin de Olmedo Airport to Panama City, these accommodation options will get you from your pillow to the plane in no time:

  • Jose Joaquin de Olmedo Airport has a strong on-time record, reducing your chances of a delayed flight. Departures from GYE make it to their destination as scheduled 89.07% of the time.

How to find the cheapest flights from Jose Joaquin de Olmedo Airport (GYE) to Panama City

  • The best price we've found for a one-way Jose Joaquin de Olmedo Airport to Panama City flight is $162. The cheapest price for a return flight is $315. Bear in mind fares can change due to availability at the time of booking.

  • Book one month before you want to fly. Pricing trends show that this is the ideal window for finding cheap flights from GYE to Panama City.

  • Organize your trip for May. That's the best month for landing the biggest deals on Jose Joaquin de Olmedo Airport to Panama City tickets. If you're flexible on when you fly, use the 'Whole month' tool to find the cheapest price across each month.

  • You don't need to keep looking every day to find out if fares have dropped when you set up a Price Alert. We'll update you as soon as there's an even bigger deal on cheap flights from GYE to Panama City.

  • Find a cheap flight from Jose Joaquin de Olmedo Airport to Panama City with the help of our filters. Choose your preferred duration, number of stops and airlines, then sort the results by 'Cheapest' to see the best deals.

Airports in Panama City

Tocumen International Airport (PTY)

  • Tocumen International Airport (PTY) is around 21 kilometers from the center of Panama City. If you're getting a cab or a ride-share, the drive will take roughly 20 minutes.

  • Traveling by public transport takes about 1 hour 5 minutes.

  • Consider staying in a hotel near PTY if you have a late flight from Jose Joaquin de Olmedo Airport to Panama City. Settle into one of these accommodation options and make your first night all about catching up on rest:

  • Explore without limits with a Tocumen International Airport rental car. Pick up your wheels from Avis, Dollar or MEX and venture far and wide through Panama City and beyond.

  • Lock in the lowest price by booking your vehicle from Tocumen International Airport about three weeks ahead of your flight from GYE to Panama City.

Marcos A. Gelabert International Airport (PAC)

  • After your flight from Jose Joaquin de Olmedo Airport to Panama City has landed, you can get to the city center in around 5 minutes by car. Central Panama City is roughly 2 kilometers from Marcos A. Gelabert International Airport (PAC).

  • If you choose to travel on public transport, the journey will take you 25 minutes or so.

  • After stepping off your GYE to Panama City flight, tuck yourself in at a hotel near PAC. These are some great accommodation options that'll help you sink into relaxation mode:

  • Thrifty, Avis and Alamo make collecting a Marcos A. Gelabert International Airport rental car quick and easy. These trusted providers are located in or around the terminal and will have you on the road before long.

  • Secure your first choice, not your last resort. Booking your ride from PAC three weeks ahead of time often means better deals and a wider selection of vehicles.

Panama Pacifico Airport (BLB)

  • Hop off your flight from Jose Joaquin de Olmedo Airport to Panama City and head straight for your hotel or jump right into sightseeing. The center of Panama City is around 16 kilometers from Panama Pacifico Airport (BLB) and usually takes 20 minutes to drive there.

  • If you don't want to make your way to the center, head for a hotel close to BLB. Get comfortable at one of these stays after your GYE to Panama City flight:

  • Whether you're looking for an economy for a solo trip or a roomy SUV to fit the whole crew comfortably, you'll find the ideal Panama Pacifico Airport rental car for your needs. Check out the range of wheels available from companies such as Sixt, Dollar and Thrifty.

  • If you're after a specific type of vehicle, book your ride from BLB around one week ahead of your flight from Jose Joaquin de Olmedo Airport to Panama City. This gives you a better shot at getting the car you prefer, as well as a better rate.

Best time to go to Panama City

  • Carefully consider your dates before securing your flight from Jose Joaquin de Olmedo Airport to Panama City. The city buzzes during high season, but prices are typically higher and major attractions can be busy. Visit Panama City in the off-season if you like a more relaxed vibe.

  • Lock in a Jose Joaquin de Olmedo Airport to Panama City flight ticket with a departure in March if you're eager to visit the city during its warmest month. Expect temperatures to range from 21ºC (70ºF) to 32ºC (90ºF).

  • February sees average temperatures of between 22ºC (72ºF) and 31ºC (88ºF). Search for a cheap ticket from GYE to Panama City around that time if you want to travel when it's cooler.

More about Panama City

  • Start your Panama City trip off on the right foot by choosing the ideal place to stay. Once you've booked your flight from Jose Joaquin de Olmedo Airport to Panama City, browse our selection of accommodation options including:

  • Every great vacation has to include some sightseeing. Casco Viejo, Panama Canal Museum and Cinta Costera are attractions you won't want to skip in Panama City.

Explore more of Panama

  • You've done Panama City, now it's time to explore more of Panama. Journey about 322 kilometers west to David to check off its popular sights. From Parque Cervantes to Altos del Rio Park and Coquito Hills Park, you've got a jam-packed schedule ahead.

  • If you're ready to explore another well-known destination in Panama, consider Santiago de Veraguas, roughly 193 kilometers south-west of Panama City. Santiago the Apostle Cathedral, Santiago de Veraguas, The Church of Jesus Christ of Latter Day Saints and La Placita San Juan De Dios are among the biggest draws.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.