Flights from Chicago to Missouri

Flight deals from Chicago to Missouri

Looking for cheap flights from Chicago to Missouri, or a last-minute trip? Find the lowest prices on one-way and round-trip flights right here.

Cape Girardeau.$144 per passenger.Departing Thu, May 29, returning Mon, Jun 2.Round-trip flight with Contour Airlines.Outbound direct flight with Contour Airlines departing from Chicago O'Hare International on Thu, May 29, arriving in Cape Girardeau.Inbound direct flight with Contour Airlines departing from Cape Girardeau on Mon, Jun 2, arriving in Chicago O'Hare International.Price includes taxes and charges.From $144, select.

Kirksville.$144 per passenger.Departing Fri, May 23, returning Mon, May 26.Round-trip flight with Contour Airlines.Outbound direct flight with Contour Airlines departing from Chicago O'Hare International on Fri, May 23, arriving in Kirksville.Inbound direct flight with Contour Airlines departing from Kirksville on Mon, May 26, arriving in Chicago O'Hare International.Price includes taxes and charges.From $144, select.

St Louis.$144 per passenger.Departing Thu, Jun 5, returning Sun, Jun 8.Round-trip flight with Southern Airways Express.Outbound indirect flight with Southern Airways Express, departing from Chicago O'Hare International on Thu, Jun 5, arriving in St Louis.Inbound indirect flight with Southern Airways Express, departing from St Louis on Sun, Jun 8, arriving in Chicago O'Hare International.Price includes taxes and charges.From $144, select.

Kansas City.$160 per passenger.Departing Fri, Jun 6, returning Mon, Jun 9.Round-trip flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departing from Chicago O'Hare International on Fri, Jun 6, arriving in Kansas City International.Inbound indirect flight with Frontier Airlines, departing from Kansas City International on Mon, Jun 9, arriving in Chicago O'Hare International.Price includes taxes and charges.From $160, select.

Springfield.$189 per passenger.Departing Thu, May 22, returning Sun, May 25.Round-trip flight with American Airlines.Outbound direct flight with American Airlines departing from Chicago O'Hare International on Thu, May 22, arriving in Springfield-Branson Rg.Inbound direct flight with American Airlines departing from Springfield-Branson Rg on Sun, May 25, arriving in Chicago O'Hare International.Price includes taxes and charges.From $189, select.

Joplin.$243 per passenger.Departing Thu, May 29, returning Sun, Jun 1.Round-trip flight with United.Outbound direct flight with United departing from Chicago O'Hare International on Thu, May 29, arriving in Joplin.Inbound direct flight with United departing from Joplin on Sun, Jun 1, arriving in Chicago O'Hare International.Price includes taxes and charges.From $243, select.

Columbia.$259 per passenger.Departing Tue, Jun 17, returning Tue, Jun 24.Round-trip flight with American Airlines.Outbound direct flight with American Airlines departing from Chicago O'Hare International on Tue, Jun 17, arriving in Columbia.Inbound direct flight with American Airlines departing from Columbia on Tue, Jun 24, arriving in Chicago O'Hare International.Price includes taxes and charges.From $259, select.

Flying from Chicago to Missouri

Arm yourself with these facts on the fly.

Cheapest flight found	$143, Kirksville
Cheapest month to fly	May
Average flight time	1 hr, 29 mins
Cheapest airport to fly from	Chicago O'Hare International
Most popular airline	American Airlines

How to find cheap flights from Chicago to Missouri

We've compared the best online travel agents and flight providers on the Internet to find the cheapest plane tickets from Chicago to Missouri. Other savvy travelers recently found round-trip flights from $143 and one-way tickets from $72. Ready to join them? Here are a few tips to help you do it the smart way.

Fly from Chicago O'Hare International into Kirksville

At the moment, the lowest-priced flight tickets to Missouri are from Chicago O'Hare International Airport to Kirksville Airport.

Fly in July

We crunched the flight calendar and found the cheapest time to fly from Chicago to Missouri is currently July.

Fly on a Friday

From our data, we can see that Friday seems to be the cheapest time to fly from Chicago to Missouri.

Flex your dates for the best rates

If you’re flexible on your departure dates, you can use Skyscanner's whole month tool to find the cheapest day of the year to fly from Chicago to anywhere you choose in Missouri.

Watch as flight prices go up and down

With Price Alerts, we'll let you know when flight prices from Chicago to Missouri go up or down so you can book when the time is just right.

Relax – these are fee-free plane tickets

With us, there are no added fees – the Chicago to Missouri flight price you see when you search with us is what you pay to the provider.

Frequently asked questions

What's the average Chicago to Missouri flight price?

We looked at all of the upcoming round-trip flights from Chicago to Missouri we could find over the next 12 months. It looks like $143 is the best price. This is good, compared to the average Missouri ticket price of $241.

What is the cheapest month to fly from Chicago to Missouri?

The cheapest month to fly from Chicago to Springfield-Branson Rg Airport is usually May. The cheapest month to fly from Chicago to Joplin Airport is usually May. The cheapest month to fly from Chicago to Kansas City International Airport is usually June. And the cheapest month to fly from Chicago to St Louis Airport is usually June.

On which upcoming date is it cheapest to fly from Chicago to Missouri?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Chicago to Missouri on Friday, May 23, 2025.

Are there any direct flights from Chicago to Missouri?

Chicago O'Hare International Airport and Chicago Midway Airport all offer direct flights to Missouri.

If I'm flying from Chicago, where in Missouri is cheapest to fly to?

If you're flying from Chicago, the cheapest city in Missouri to fly into is Kirksville. The cheapest airport serving Kirksville at the moment is Kirksville.