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Flights from Knoxville to South Carolina

Flight deals from Knoxville to South Carolina

Looking for cheap flights from Knoxville to South Carolina, or a last-minute trip? Find the lowest prices on one-way and round-trip flights right here.
Charleston.$271 per passenger.Departing Wed, Dec 31, returning Sun, Jan 4.Round-trip flight with Allegiant Air and Spirit Airlines.Outbound indirect flight with Allegiant Air, departing from Knoxville on Wed, Dec 31, arriving in Charleston.Inbound indirect flight with Spirit Airlines, departing from Charleston on Sun, Jan 4, arriving in Knoxville.Price includes taxes and charges.From $271, select.
Myrtle Beach.$298 per passenger.Departing Wed, Dec 31, returning Sun, Jan 4.Round-trip flight with Allegiant Air and Spirit Airlines.Outbound indirect flight with Allegiant Air, departing from Knoxville on Wed, Dec 31, arriving in Myrtle Beach International.Inbound indirect flight with Spirit Airlines, departing from Myrtle Beach International on Sun, Jan 4, arriving in Knoxville.Price includes taxes and charges.From $298, select.
Greenville.$335 per passenger.Departing Tue, Dec 30, returning Sat, Jan 3.Round-trip flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departing from Knoxville on Tue, Dec 30, arriving in Greenville-Spartanburg.Inbound indirect flight with Allegiant Air, departing from Greenville-Spartanburg on Sat, Jan 3, arriving in Knoxville.Price includes taxes and charges.From $335, select.
Columbia.$748 per passenger.Departing Mon, Dec 29, returning Fri, Jan 2.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Knoxville on Mon, Dec 29, arriving in Columbia Metropolitan.Inbound indirect flight with Delta, departing from Columbia Metropolitan on Fri, Jan 2, arriving in Knoxville.Price includes taxes and charges.From $748, select.
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Flying from Knoxville to South Carolina

Arm yourself with these facts on the fly.
Cheapest flight found$271
Cheapest month to flyDecember
Cheapest airport to fly fromKnoxville

Frequently asked questions

We looked at all of the upcoming round-trip flights from Knoxville to South Carolina we could find over the next 12 months. It looks like $271 is the best price. This is good, compared to the average South Carolina ticket price of $413.
The cheapest month to fly from Knoxville to Columbia Metropolitan Airport is usually December. The cheapest month to fly from Knoxville to Charleston Airport is usually December. The cheapest month to fly from Knoxville to Greenville-Spartanburg Airport is usually December. And the cheapest month to fly from Knoxville to Myrtle Beach International Airport is usually December.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Knoxville to South Carolina on Wednesday, December 31, 2025.
Currently, there aren't any direct flights from Knoxville to South Carolina, but you can still fly with a stopover.
If you're flying from Knoxville, the cheapest city in South Carolina to fly into is Charleston. The cheapest airport serving Charleston at the moment is Charleston.