Cheap Flights from Santa Ana John Wayne CA to St Louis MO from $309

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Flight deals from Santa Ana John Wayne to St Louis

Looking for a cheap last-minute deal or the best round-trip flight from Santa Ana John Wayne Airport to St Louis Airport? If you want to travel next month, round-trip fares start from $309. Find the lowest prices on one-way and round-trip tickets right here.

St Louis.$309 per passenger.Departing Tue, Oct 27, returning Wed, Oct 28.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Tue, Oct 27, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Wed, Oct 28, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $309, select.

St Louis.$313 per passenger.Departing Wed, Oct 28, returning Mon, Nov 2.Round-trip flight with Breeze Airways and Frontier Airlines.Outbound indirect flight with Breeze Airways, departing from Santa Ana John Wayne on Wed, Oct 28, arriving in St Louis.Inbound indirect flight with Frontier Airlines, departing from St Louis on Mon, Nov 2, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $313, select.

St Louis.$375 per passenger.Departing Thu, Feb 11, returning Wed, Feb 17.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Thu, Feb 11, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Wed, Feb 17, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $375, select.

St Louis.$394 per passenger.Departing Thu, Nov 5, returning Fri, Nov 6.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Thu, Nov 5, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Fri, Nov 6, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $394, select.

St Louis.$493 per passenger.Departing Fri, Dec 25, returning Tue, Jan 12.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Fri, Dec 25, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Tue, Jan 12, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $493, select.

St Louis.$502 per passenger.Departing Fri, Mar 12, returning Fri, Mar 26.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Fri, Mar 12, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Fri, Mar 26, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $502, select.

St Louis.$600 per passenger.Departing Tue, Sep 29, returning Mon, Oct 5.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Tue, Sep 29, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Mon, Oct 5, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $600, select.

St Louis.$618 per passenger.Departing Mon, Dec 21, returning Sat, Dec 26.Round-trip flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departing from Santa Ana John Wayne on Mon, Dec 21, arriving in St Louis.Inbound indirect flight with Frontier Airlines, departing from St Louis on Sat, Dec 26, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $618, select.

St Louis.$643 per passenger.Departing Wed, Sep 23, returning Sat, Sep 26.Round-trip flight with Breeze Airways and Frontier Airlines.Outbound indirect flight with Breeze Airways, departing from Santa Ana John Wayne on Wed, Sep 23, arriving in St Louis.Inbound indirect flight with Frontier Airlines, departing from St Louis on Sat, Sep 26, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $643, select.

St Louis.$9,941 per passenger.Departing Fri, Jan 8, returning Fri, Jan 22.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Fri, Jan 8, arriving in St Louis.Inbound indirect flight with Alaska Airlines, departing from St Louis on Fri, Jan 22, arriving in Santa Ana John Wayne.Price includes taxes and charges.From $9,941, select.

Find the cheapest month to fly from Santa Ana John Wayne to St Louis

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santa Ana John Wayne to St Louis flights are currently cheapest in October.

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Santa Ana John Wayne to St Louis: Alternative routes

Compare routes from Santa Ana John Wayne to St Louis below. You may find an airport to fly into that's cheaper, faster, or easier than St Louis.

St Louis

20km from central St Louis

ClosestCheapest

from $309

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Belleville

32km from central St Louis

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Santa Ana to St Louis: Flight information

The things to know before you go.

Cheapest flight found	$309
Cheapest month to fly	October

Finding cheap flights from Santa Ana John Wayne to St Louis: Frequently asked questions

How much are round-trip flights from Santa Ana John Wayne to St Louis?

The best price we found for a round-trip flight from Santa Ana John Wayne to St Louis is $309. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Santa Ana John Wayne to St Louis?

Currently, there are no airlines that fly direct from Santa Ana John Wayne to St Louis. But we found flights with one or more stops from $309.

How many flights are there a week from Santa Ana John Wayne to St Louis?

There are no flights flying from Santa Ana John Wayne to St Louis, as of September 2026.

When is the cheapest time to fly from Santa Ana John Wayne to St Louis?

The cheapest month to fly from Santa Ana John Wayne to St Louis is usually October.

Which upcoming date is cheapest to fly from Santa Ana John Wayne Airport to St Louis Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Santa Ana John Wayne Airport to St Louis Airport on Tuesday, October 27, 2026.

Can I get a direct flight from Santa Ana John Wayne Airport to St Louis Airport?

No airlines currently offer direct flights between Santa Ana John Wayne Airport and St Louis Airport. Most routes have one or more stops.

How can I find the best flight deal to St Louis?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to St Louis but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to St Louis?

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to St Louis is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly with from Santa Ana John Wayne Airport to St Louis?

Currently, Alaska Airlines offers the cheapest flight tickets to St Louis.

Traveling from Santa Ana John Wayne Airport (SNA) to St Louis Airport (STL): what you need to know

The timezone in St Louis is UTC-6, which is two hours ahead of Santa Ana.
Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules worth sticking to. Make sure you're at the airport on time to catch your SNA to STL flight.
You can expect bigger queues in popular months such as July. Arriving up to four hours in advance for international flights and two hours for a domestic departure will help ensure a smooth travel experience.
We make it a breeze to book a flight with a stopover. To see all your options for tickets from Santa Ana John Wayne Airport to St Louis Airport, deselect 'Direct flights only.' Then, pick a flight offering a stop long enough to tour your chosen city. Worthwhile stopovers between SNA and STL include:
- Denver International Airport
- Phoenix Sky Harbor Airport
- Harry Reid International Airport

How to find the cheapest flights from Santa Ana John Wayne Airport (SNA) to St Louis Airport (STL)

The cheapest price we've seen for a one-way Santa Ana John Wayne Airport to St Louis Airport flight is $165. A return ticket is currently $309. Depending on the availability and when you book, these fares can change.
To pick up cheap tickets from SNA to STL, book as early as you can. Airlines typically offer lower fares when flights are first made available.
The 'Whole month' tool shows you the cheapest flights from Santa Ana John Wayne Airport to St Louis Airport across the month. It's a good way to find a bargain if your plans are flexible.
Snapping up cheap flights from SNA to STL couldn't be easier with Price Alerts. Simply create one of these automatic alerts and we'll notify you when a new deal comes up.
Select your ideal departure and arrival times, airlines and number of stops with the filters. Or sort your results by 'Cheapest' to find the best deals on flights from Santa Ana John Wayne Airport to St Louis Airport.

Handy information about Santa Ana John Wayne Airport (SNA)

You'll find SNA at 18601 Airport Way.
Santa Ana John Wayne Airport maintains a solid on-time record, so you're less likely to experience disruptions. Departures from SNA touch down on schedule 81% of the time.
Central Santa Ana to Santa Ana John Wayne Airport is around 6 kilometers. Depending on traffic, it'll take about 10 minutes to get there if you're ride-sharing, catching a cab or driving.
The journey on public transport usually takes 30 minutes.
Catching an early flight from Santa Ana John Wayne Airport to St Louis Airport? Avoid the last-minute rush to the airport (and catch some extra z's) by picking one of these stays close to SNA:

Arriving at St Louis Airport (STL)

Book a hotel near STL if you're taking a late Santa Ana John Wayne Airport to St Louis Airport flight. Settle into one of these options and make your arrival easier:
Hit the road running by picking up a St Louis Airport rental car. Grab your wheels from Hertz, Budget or Alamo and experience the lesser-explored corners of St Louis and beyond.
Lock in the best possible rate by booking your vehicle from St Louis Airport around one week ahead of your trip.

When to fly to St Louis Airport (STL)

July is the most popular month for flights from Santa Ana John Wayne Airport to St Louis Airport. For a quieter experience, visit St Louis in March.
Before locking in your flight from Santa Ana John Wayne Airport to St Louis Airport, consider the kind of weather you enjoy. July is the warmest month in St Louis, with the temperature ranging from 17ºC (63ºF) to 33ºC (91ºF).
January has average temperatures of between -7ºC (19ºF) and 8ºC (46ºF). Search for cheap tickets from SNA to STL sometime then if you'd rather travel in cooler conditions.

Explore more of the United States

Chicago is just one of the many cities in the United States waiting to be discovered after you've experienced St Louis. Around 418 kilometers away to the north-east, its best attractions include Millennium Park, Art Institute of Chicago and Willis Tower.
Around 370 kilometers east of St Louis, Indianapolis is another favorite stop in the United States. No visit is complete without checking out Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.