Cheap flights from Buffalo Niagara to Santiago

Compare Buffalo Niagara to Santiago flight deals

Find the cheapest month or even day of the year to fly to Santiago

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Flight deals from Buffalo Niagara to Santiago

Looking for a cheap last-minute deal or the best round-trip flight from Buffalo Niagara Airport to Santiago Airport? If you want to travel next month, round-trip fares start from $638. Find the lowest prices on one-way and round-trip tickets right here.

Santiago.$638 per passenger.Departing Tue, Aug 4, returning Mon, Aug 10.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Buffalo Niagara on Tue, Aug 4, arriving in Santiago.Inbound indirect flight with Delta, departing from Santiago on Mon, Aug 10, arriving in Buffalo Niagara.Price includes taxes and charges.From $638, select.

Santiago.$738 per passenger.Departing Fri, Jul 31, returning Thu, Aug 6.Round-trip flight with Frontier Airlines and jetBlue.Outbound indirect flight with Frontier Airlines, departing from Buffalo Niagara on Fri, Jul 31, arriving in Santiago.Inbound indirect flight with jetBlue, departing from Santiago on Thu, Aug 6, arriving in Buffalo Niagara.Price includes taxes and charges.From $738, select.

Santiago.$821 per passenger.Departing Wed, Dec 16, returning Wed, Dec 23.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Buffalo Niagara on Wed, Dec 16, arriving in Santiago.Inbound indirect flight with Delta, departing from Santiago on Wed, Dec 23, arriving in Buffalo Niagara.Price includes taxes and charges.From $821, select.

Santiago.$893 per passenger.Departing Fri, Jul 10, returning Mon, Jul 27.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Buffalo Niagara on Fri, Jul 10, arriving in Santiago.Inbound indirect flight with Delta, departing from Santiago on Mon, Jul 27, arriving in Buffalo Niagara.Price includes taxes and charges.From $893, select.

Find the cheapest month to fly from Buffalo Niagara to Santiago

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Buffalo Niagara to Santiago flights are currently cheapest in August.

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Buffalo Niagara to Santiago: Alternative routes

Compare routes from Buffalo Niagara to Santiago below. You may find an airport to fly into that's cheaper, faster, or easier than Santiago.

Santiago

2km from central Santiago

ClosestCheapest

from $636

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Puerto Plata

36km from central Santiago

from $658

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Buffalo to Santiago: Flight information

The things to know before you go.

Cheapest flight found	$638
Cheapest month to fly	August

Finding cheap flights from Buffalo Niagara to Santiago: Frequently asked questions

How much are round-trip flights from Buffalo Niagara to Santiago?

The best price we found for a round-trip flight from Buffalo Niagara to Santiago is $638. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Buffalo Niagara to Santiago?

Currently, there are no airlines that fly direct from Buffalo Niagara to Santiago. But we found flights with one or more stops from $638.

How many flights are there a week from Buffalo Niagara to Santiago?

There are no flights flying from Buffalo Niagara to Santiago, as of July 2026.

When is the cheapest time to fly from Buffalo Niagara to Santiago?

The cheapest month to fly from Buffalo Niagara to Santiago is usually August.

Which upcoming date is cheapest to fly from Buffalo Niagara Airport to Santiago Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Buffalo Niagara Airport to Santiago Airport on Tuesday, August 4, 2026.

Can I get a direct flight from Buffalo Niagara Airport to Santiago Airport?

No airlines currently offer direct flights between Buffalo Niagara Airport and Santiago Airport. Most routes have one or more stops.

How can I find the best flight deal to Santiago?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santiago but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Santiago?

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Santiago is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly with from Buffalo Niagara Airport to Santiago?

Currently, Delta offers the cheapest flight tickets to Santiago.

Flying from Buffalo Niagara Airport (BUF) to Santiago Airport (STI): what you need to know

Santiago is one hour ahead of Buffalo and is in the UTC-4 timezone.
Leave enough time to catch your BUF to STI flight. Generally, it's best to arrive two hours before international departures and an hour ahead for domestic flights.
Traveling during a peak time such as August? School holidays and other popular periods can result in longer lines and delays at check-in and security. Be extra cautious and get there up to four hours ahead of an international flight and two hours before a domestic departure.
We make it a piece of cake to book a flight with a stopover. To see your options for tickets from Buffalo Niagara Airport to Santiago Airport, deselect 'Direct flights only.' Then, choose a flight offering a stop long enough to tour the city of your choice. Popular stopovers between BUF and STI include:
- New York John F. Kennedy Airport
- New York Newark Airport
- Miami International Airport

How to find the cheapest flights from Buffalo Niagara Airport (BUF) to Santiago Airport (STI)

At the moment, $191 is the lowest price we've seen for a one-way Buffalo Niagara Airport to Santiago Airport flight. The best price for a return plane ticket is $636. Bear in mind that fares could change due to availability at the time of booking.
It's usually smart to book early if you want to find cheap tickets from BUF to STI. That's because flight prices are based on demand, which tends to rise closer to departure.
Getting cheap flights from Buffalo Niagara Airport to Santiago Airport is more likely if you can be flexible with your dates. Use the 'Whole month' search function to see the lowest fares throughout the month and land a great deal.
Stay on top of deals for cheap flights from BUF to STI by creating a Price Alert. You'll get an email or notification through the app when a special offer becomes available.
Choose your ideal departure and arrival times, number of stops and airlines with the filters. Alternatively, sort your results by 'Cheapest' to see the best deals on flights from Buffalo Niagara Airport to Santiago Airport.

Handy information about Buffalo Niagara Airport (BUF)

You'll find BUF at Genesee Street.
74% of flights taking off from Buffalo Niagara Airport touch down at their destination on schedule.
Central Buffalo to Buffalo Niagara Airport is approximately 16 kilometers. Depending on traffic, it'll take you about 20 minutes to get there if you're catching a cab, ride-sharing or driving.
The trip when using public transport will take about 40 minutes.
Get your journey off to a leisurely start by staying near BUF. Whether you're taking an early flight from Buffalo Niagara Airport to Santiago Airport or just don't want to be rushed, these hotels are ideal:

Arriving at Santiago Airport (STI)

If you're landing on a late Buffalo Niagara Airport to Santiago Airport flight, few things top the convenience of staying close to the terminal. Grab your luggage from the carousel and then be resting soon after at one of these accommodation options near STI:
Get on the fast track to adventure by picking up a Santiago Airport rental car. Grab your wheels from America, Zezgo Rent a Car or Alamo and explore beyond Santiago's main sights.
For the lowest price, book your ride from Santiago Airport around one week in advance.

When to fly to Santiago Airport (STI)

August is the most popular month for flights from Buffalo Niagara Airport to Santiago Airport. To skip the crowds, travel to Santiago in October.
When booking your flight from Buffalo Niagara Airport to Santiago Airport, consider the kind of weather you enjoy. August is the warmest month in Santiago, with the temperature ranging from 21ºC (70ºF) to 33ºC (91ºF).
Look for cheap tickets from BUF to STI in January if you like traveling in cooler conditions. Temperatures are at their lowest then, ranging between 16ºC (61ºF) and 29ºC (84ºF) on average.

Explore more of the Dominican Republic

Santiago is always a good idea, but there are so many other corners of the Dominican Republic just waiting to be explored. Around 137 kilometers south-east of Santiago, a trip to Santo Domingo will keep your itinerary packed. Don't miss top attractions like Catedral Primada de las Americas, Alcazar de Colon and The Cathedral of the Americas.
Santo Domingo Este is another standout destination in the Dominican Republic and is around 145 kilometers south-east of Santiago. No trip is complete without visiting Lago los tres ojos, National Aquarium and La Cueva del Eden.