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Cheap flights from Des Moines to Panama City

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      Compare Des Moines to Panama City flight deals

      Find the cheapest month or even day of the year to fly to Panama City

      Book the best Panama City fare with no extra fees

      Flight deals from Des Moines to Panama City

      Looking for a cheap last-minute deal or the best round-trip flight from Des Moines Airport to Panama City? If you want to travel next month, round-trip fares start from $702. Find the lowest prices on one-way and round-trip tickets right here.
      Panama City.$687 per passenger.Departing Thu, Oct 8, returning Sun, Oct 11.Round-trip flight with United.Outbound indirect flight with United, departing from Des Moines on Thu, Oct 8, arriving in Panama City Tocumen International.Inbound indirect flight with United, departing from Panama City Tocumen International on Sun, Oct 11, arriving in Des Moines.Price includes taxes and charges.From $687, select.
      Panama City.$702 per passenger.Departing Fri, Jul 10, returning Fri, Jul 17.Round-trip flight with United.Outbound indirect flight with United, departing from Des Moines on Fri, Jul 10, arriving in Panama City Tocumen International.Inbound indirect flight with United, departing from Panama City Tocumen International on Fri, Jul 17, arriving in Des Moines.Price includes taxes and charges.From $702, select.
      Panama City.$702 per passenger.Departing Fri, Aug 21, returning Tue, Aug 25.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Fri, Aug 21, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departing from Panama City Tocumen International on Tue, Aug 25, arriving in Des Moines.Price includes taxes and charges.From $702, select.
      Panama City.$964 per passenger.Departing Sat, Jan 23, returning Sat, Feb 6.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Sat, Jan 23, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departing from Panama City Tocumen International on Sat, Feb 6, arriving in Des Moines.Price includes taxes and charges.From $964, select.
      Panama City.$1,083 per passenger.Departing Tue, Dec 15, returning Tue, Dec 22.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Tue, Dec 15, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departing from Panama City Tocumen International on Tue, Dec 22, arriving in Des Moines.Price includes taxes and charges.From $1,083, select.
      Panama City.$1,120 per passenger.Departing Thu, Sep 3, returning Mon, Sep 7.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Thu, Sep 3, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departing from Panama City Tocumen International on Mon, Sep 7, arriving in Des Moines.Price includes taxes and charges.From $1,120, select.

      Alternative Des Moines to Panama City routes

      Looking for the cheapest, fastest or easiest route from Des Moines to Panama City? You could fly into the following airports instead.

      Panama City Paitilla

      5km from central Panama City
      Closest
      Search flights

      Balboa

      5km from central Panama City
      from $859
      Search flights

      Panama City Tocumen International

      18km from central Panama City
      Cheapest
      from $687
      Search flights

      Des Moines to Panama City: Flight information

      The things to know before you go.
      Cheapest flight found$687
      Cheapest month to flyOctober

      Finding cheap flights from Des Moines to Panama City: Frequently asked questions

      There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
      The best price we found for a round-trip flight from Des Moines to Panama City is $687. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      Currently, there are no airlines that fly direct from Des Moines to Panama City. But we found flights with one or more stops from $687.
      There are no flights flying from Des Moines to Panama City, as of July 2026.
      The cheapest month to fly from Des Moines to Panama City is usually October.
      If you're flying from Des Moines Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the center of Panama City. We've found flights to this airport from $687.
      After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Panama City on Thursday, October 8, 2026.
      No airlines currently offer direct flights between Des Moines Airport and Panama City. Most routes have one or more stops.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

      In July, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
      Currently, United offers the cheapest flight tickets to Panama City.

      Traveling from Des Moines International Airport (DSM) to Panama City: what you need to know

      • Panama City is one hour ahead of Des Moines, where Des Moines International Airport is located. Panama City follows the UTC-5 timezone.

      • Give yourself enough time to make your DSM to Panama City flight. It's generally best to arrive at least two hours before international departures and an hour ahead for domestic flights.

      • You'll likely experience longer queues during popular months like July. Arriving up to four hours ahead of an international flight and two hours for a domestic departure is a wise move.

      • A stopover is the perfect opportunity to break up your trip and maybe even explore a different city. When searching for plane tickets from DSM to Panama City, deselect the 'Direct flights only' box to see where you can stop along the way. Popular options include:

        • Atlanta Hartsfield-Jackson International Airport (ATL)

        • Houston George Bush Intercontinental Airport (IAH)

        • Miami International Airport (MIA)

      • Located around 6 kilometers from central Des Moines, DSM can be reached in about 15 minutes by car. Traveling on public transport takes roughly 30 minutes.

      • Searching for a hotel close to DSM? If you're catching an early flight from Des Moines International Airport to Panama City, these stays will get you from your pillow to the plane in no time:

      • 77% of flights taking off from Des Moines International Airport land at their destination on time.

      • DSM is located at 5800 Fleur Drive, Suite 201.

      How to find the cheapest flights from Des Moines International Airport (DSM) to Panama City

      • $313 is currently the best price for a one-way Des Moines International Airport to Panama City flight. A return plane ticket starts from $687. These fares may change depending on demand and availability.

      • Booking early is often the key to securing a cheap flight from DSM to Panama City. Flight prices rise as demand increases, so the closer you get to departure, the more you'll likely pay.

      • If you have flexibility with your trip dates, use the 'Whole month' tool. It'll find the cheapest price across each month when looking for a Des Moines International Airport to Panama City ticket.

      • Save time searching for cheap flights from DSM to Panama City by setting up a Price Alert. You'll get an email or notification on the app when fares go down.

      • Select your preferred arrival and departure times, airlines and number of stops with our filters. Then, sort the results for your flight from Des Moines International Airport to Panama City by 'Cheapest,' 'Best' or 'Fastest.'

      Airports in Panama City

      Panama City Tocumen International Airport (PTY)

      • Panama City Tocumen International Airport (PTY) is around 24 kilometers from central Panama City. If you're grabbing a cab or a ride-share, the drive will take roughly 35 minutes.

      • When traveling by public transport, expect a journey time of about 50 minutes.

      • The last thing you want is a lengthy journey to your hotel if you're arriving on a late flight from Des Moines International Airport to Panama City. Check in to one of these accommodation options near PTY instead:

      • Reserving your ride from Panama City Tocumen International Airport about three weeks in advance of your flight from DSM to Panama City can help you get the best possible rate.

      Panama Pacifico International Airport (BLB)

      • Once your flight from Des Moines International Airport to Panama City has touched down, you can reach the city center in around 10 minutes by car. Central Panama City is roughly 6 kilometers from Panama Pacifico International Airport (BLB).

      • The journey will take about 20 minutes on public transport.

      • Following your DSM to Panama City flight, unwind at a hotel near BLB. These are some comfortable options that'll help you get into relaxation mode:

      • Avoid last-minute price surges. Booking your ride one week before your arrival at BLB will save you money.

      Best time to go to Panama City

      • January is the most popular month for flights from Des Moines International Airport to Panama City. To skip the crowds, visit Panama City in September.

      • The warmest month in Panama City is March, with temperatures ranging between 21ºC (70ºF) and 32ºC (90ºF). Lock in your Des Moines International Airport to Panama City plane ticket then if you enjoy this type of weather.

      • January has average temperatures of between 22ºC (72ºF) and 31ºC (88ºF). Look for a cheap ticket from DSM to Panama City around that time if you like cooler conditions.

      More about Panama City

      • After booking your flight from Des Moines International Airport to Panama City, find a hotel that keeps you close to what you want to see. Make one of these options your base for exploring Panama City:

      • There are so many things to see and do in this city it can be hard to work out where to start. Metropolitan Cathedral (Catedral Metropolitan), Casco Viejo and Independence Square are highlights which should be on any well-planned Panama City itinerary.

      Explore more of Panama

      • Panama City has loads to offer, but there are so many other corners of Panama just waiting to be explored. Around 322 kilometers west of Panama City, a trip to David will keep you busy. Start with popular sights like Museo Antropológico y Etnográfico Dr. Roberto De La Guardia, Raptors To The Rescue and Unachi Botanical garden.

      • Another major destination in Panama, Santiago de Veraguas is around 193 kilometers southwest of Panama City. Plan to visit highlights including Santiago the Apostle Cathedral, Santiago de Veraguas.

      More travel options

      Plan the rest of your trip from Des Moines to Panama City

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.