Cheap Flights from Des Moines to Rome

Compare Des Moines to Rome flight deals

Find the cheapest month or even day of the year to fly to Rome

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Flight deals from Des Moines Airport to Rome

Looking for a cheap last-minute deal or the best round-trip flight from Des Moines Airport to Rome? If you want to travel next month, round-trip fares start from $1,203. Find the lowest prices on one-way and round-trip tickets right here.

Rome.$789 per passenger.Departing Sun, Dec 6, returning Tue, Dec 15.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Sun, Dec 6, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departing from Rome Fiumicino on Tue, Dec 15, arriving in Des Moines.Price includes taxes and charges.From $789, select.

Rome.$821 per passenger.Departing Sun, Aug 2, returning Thu, Aug 20.Round-trip flight with Air France.Outbound indirect flight with Air France, departing from Des Moines on Sun, Aug 2, arriving in Rome Fiumicino.Inbound indirect flight with Air France, departing from Rome Fiumicino on Thu, Aug 20, arriving in Des Moines.Price includes taxes and charges.From $821, select.

Rome.$901 per passenger.Departing Tue, May 12, returning Tue, May 19.Round-trip flight with Air Canada and Lufthansa.Outbound indirect flight with Air Canada, departing from Des Moines on Tue, May 12, arriving in Rome Fiumicino.Inbound indirect flight with Lufthansa, departing from Rome Fiumicino on Tue, May 19, arriving in Des Moines.Price includes taxes and charges.From $901, select.

Rome.$980 per passenger.Departing Fri, Sep 4, returning Fri, Sep 11.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Fri, Sep 4, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departing from Rome Fiumicino on Fri, Sep 11, arriving in Des Moines.Price includes taxes and charges.From $980, select.

Rome.$1,069 per passenger.Departing Fri, Aug 28, returning Tue, Sep 8.Round-trip flight with Allegiant Air and Wizz Air Malta.Outbound indirect flight with Allegiant Air, departing from Des Moines on Fri, Aug 28, arriving in Rome Fiumicino.Inbound indirect flight with Wizz Air Malta, departing from Rome Fiumicino on Tue, Sep 8, arriving in Des Moines.Price includes taxes and charges.From $1,069, select.

Rome.$1,088 per passenger.Departing Tue, Jul 21, returning Thu, Jul 30.Round-trip flight with Allegiant Air and Ryanair.Outbound indirect flight with Allegiant Air, departing from Des Moines on Tue, Jul 21, arriving in Rome Fiumicino.Inbound indirect flight with Ryanair, departing from Rome Ciampino on Thu, Jul 30, arriving in Des Moines.Price includes taxes and charges.From $1,088, select.

Rome.$1,203 per passenger.Departing Fri, Apr 3, returning Mon, Apr 6.Round-trip flight with Delta.Outbound indirect flight with Delta, departing from Des Moines on Fri, Apr 3, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departing from Rome Fiumicino on Mon, Apr 6, arriving in Des Moines.Price includes taxes and charges.From $1,203, select.

Rome.$1,238 per passenger.Departing Sat, Jun 6, returning Wed, Jun 17.Round-trip flight with Allegiant Air and Iberia.Outbound indirect flight with Allegiant Air, departing from Des Moines on Sat, Jun 6, arriving in Rome Fiumicino.Inbound indirect flight with Iberia, departing from Rome Fiumicino on Wed, Jun 17, arriving in Des Moines.Price includes taxes and charges.From $1,238, select.

Find the cheapest month to fly from Des Moines to Rome

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Rome flights are currently cheapest in December.

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Alternative Des Moines to Rome routes

Looking for the cheapest, fastest or easiest route from Des Moines to Rome? You could fly into the following airports instead.

Rome Ciampino

13km from central Rome

Closest

from $1,074

Search flights

Rome Fiumicino

23km from central Rome

Cheapest

from $789

Search flights

Des Moines to Rome: Flight information

The things to know before you go.

Cheapest flight found	$354
Cheapest month to fly	October

Finding cheap flights from Des Moines to Rome: Frequently asked questions

How many airports are there in Rome?

There are 2 airports in Rome: Rome Ciampino and Rome Fiumicino.

How much are round-trip flights from Des Moines to Rome?

The best price we found for a round-trip flight from Des Moines to Rome is $789. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Des Moines to Rome?

Currently, there are no airlines that fly direct from Des Moines to Rome. But we found flights with one or more stops from $789.

How many flights are there a week from Des Moines to Rome?

There are no flights flying from Des Moines to Rome, as of March 2026.

When is the cheapest time to fly from Des Moines to Rome?

The cheapest month to fly from Des Moines to Rome is usually December.

What's the cheapest airport to fly to in Rome?

If you're flying from Des Moines Airport, the cheapest airport near Rome is Rome Fiumicino – which is 22.9 km away from the center of Rome. We've found flights to this airport from $789.

Which upcoming date is cheapest to fly from Des Moines Airport to Rome on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Rome on Sunday, December 6, 2026.

Can I get a direct flight from Des Moines Airport to Rome?

No airlines currently offer direct flights between Des Moines Airport and Rome. Most routes have one or more stops.

How can I get the best flight deal from Des Moines Airport to Rome?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Rome but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Rome?

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Rome is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Rome?

In March, the average temperature is usually around 11°C. August is typically the warmest month in Rome, when it usually averages around 30°C. You can expect the least rain in July. The coldest month is January, with temperatures averaging 5°C. The rainiest month is November.

Which is the cheapest airline to fly with from Des Moines Airport to Rome?

Currently, Delta offers the cheapest flight tickets to Rome.

Flying from Des Moines International Airport (DSM) to Rome: what you need to know

Rome is six hours ahead of Des Moines, where Des Moines International Airport is located. Rome runs on the UTC+1 timezone.
Allow plenty of time to make your DSM to Rome flight. As a general rule, arrive at least two hours before international departures and an hour ahead for domestic flights.
Longer lines at check-in and security are more likely if you're heading away during high season, so give yourself even more breathing space. A good rule of thumb for peak periods? Get there up to four hours early for international flights and at least two hours for domestic departures.
Consider adding a stopover to potentially save on your flight ticket from DSM to Rome. Simply deselect 'Direct flights only' during your search. Break up your journey by stopping at one of these popular airports:
- O'Hare International Airport (ORD)
- Hartsfield-Jackson Atlanta International Airport (ATL)
- Detroit Metropolitan Wayne County Airport (DTW)
Located around 6 kilometers from central Des Moines, DSM can be reached in about 15 minutes by car (depending on traffic). The journey on public transport will take roughly 45 minutes.
Catching an early flight from Des Moines International Airport to Rome? Avoid the last-minute rush to the airport (and enjoy a little extra shut-eye) by choosing one of these stays near DSM:
80.45% of flights leaving Des Moines International Airport land at their destination as planned. Given its solid on-time performance, you're unlikely to experience delays when setting off from DSM.
DSM is located at 5800 Fleur Drive, Suite 201.

How to find the cheapest flights from Des Moines International Airport (DSM) to Rome

The lowest price we've seen for a one-way Des Moines International Airport to Rome flight is $354. The cheapest price for a return flight is $789. Keep in mind fares can change due to availability at the time of booking.
Don't leave everything to the last moment. You're more likely to land cheap flights from DSM to Rome if you book ahead. Airlines often have some great early bird deals.
Landing cheap tickets from Des Moines International Airport to Rome is easier if you can be flexible with your trip dates. Use the 'Whole month' search tool to access the lowest prices across each month and score a fantastic deal.
There's no need to check every day to see if fares have dropped when you create a Price Alert. We'll let you know the moment there's an even better deal on cheap flights from DSM to Rome.
Find an affordable flight from Des Moines International Airport to Rome with the help of our filters. Select your ideal times, airlines and number of stops, then sort the results by 'Cheapest' to see the best deals.

Airports in Rome

Leonardo da Vinci-Fiumicino Airport (FCO)

Leonardo da Vinci-Fiumicino Airport (FCO) to central Rome takes about 40 minutes to reach by car. The center is roughly 32 kilometers away.
It takes around 50 minutes when traveling by public transport.
The last thing you need is a long journey to your hotel if you're landing late on a flight from Des Moines International Airport to Rome. Reserve one of these accommodation options near FCO instead:
Go where the road takes you with a Leonardo da Vinci-Fiumicino Airport rental car. Pick up a set of wheels from Surprice, RentSmart24 or Noleggiare and discover more of Rome and beyond.
Booking your vehicle from Leonardo da Vinci-Fiumicino Airport around three weeks in advance of your flight from DSM to Rome can help you get the best possible rate.

Ciampino-G. B. Pastine International Airport (CIA)

Central Rome is located around 18 kilometers from Ciampino-G. B. Pastine International Airport (CIA). Once your flight from Des Moines International Airport to Rome has landed and you've made your way out of the airport, expect a drive of about 40 minutes.
If you're traveling on public transport, it'll take around 1 hour 40 minutes.
Place the 'Do not disturb' sign on your door and relax at a hotel near CIA. Here are a few options where you can take a load off after your DSM to Rome flight:
The quickest way to reach your destination is with a Ciampino-G. B. Pastine International Airport rental car. Grab a set of wheels from RentSmart24, Sicily by Car or Surprice and get going in the blink of an eye.
Avoid potential price surges. Booking your ride one week ahead of your arrival at CIA will help you save.

Best time to go to Rome

Carefully consider your trip dates before locking in your flight from Des Moines International Airport to Rome. The city buzzes in peak season, but prices are often higher and top attractions can be crowded. Go to Rome in the low season if you prefer a more relaxed vibe.
The warmest month in Rome is August, with temperatures ranging between 20ºC (68ºF) and 33ºC (91ºF). Lock in your Des Moines International Airport to Rome flight ticket then if this is the type of weather you enjoy.
Look for cheap tickets from DSM to Rome in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 2ºC (36ºF) and 14ºC (57ºF) on average.

More about Rome

When it comes to searching for somewhere to lay your head, you'll find the top stays in Rome right here. Explore these hotels as soon as you've booked your flight from Des Moines International Airport to Rome:
There are so many things to discover in this city it can be hard to figure out where to begin. Trevi Fountain, Colosseum and Roman Forum are leading attractions which should be on any well-planned Rome itinerary.

Explore more of Italy

Rome will leave a lasting impression, but there are so many other corners of Italy just waiting to be discovered. About 483 kilometers north-west of Rome, a trip to Milan will fill your itinerary to the brim. Don't miss top attractions like Grande Museo del Duomo di Milano, Milan Cathedral and The Last Supper Museum.
If you want to check out another great destination in Italy, head for Naples, about 193 kilometers south-east of Rome. National Archaeological Museum, Castel dell'Ovo and Royal Palace of Naples are key reasons to visit.