Cheap flights from Madison to Knoxville

Compare Madison to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

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Flight deals from Madison to Knoxville

Looking for a cheap last-minute deal or the best round-trip flight from Madison Airport to Knoxville Airport? If you want to travel next month, round-trip fares start from $322. Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from Madison to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Madison to Knoxville flights are currently cheapest in August.

Madison to Knoxville: Alternative routes

Compare routes from Madison to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Madison to Knoxville: Flight information

The things to know before you go.
Cheapest flight found$225
Cheapest month to flyJuly

Finding cheap flights from Madison to Knoxville: Frequently asked questions

The best price we found for a round-trip flight from Madison to Knoxville is $225. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Madison to Knoxville. But we found flights with one or more stops from $225.
There are no flights flying from Madison to Knoxville, as of July 2026.
The cheapest month to fly from Madison to Knoxville is usually July.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Madison Airport to Knoxville Airport on Thursday, July 30, 2026.
No airlines currently offer direct flights between Madison Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Traveling from Madison Airport (MSN) to Knoxville Airport (TYS): what you need to know

  • Arrive at the airport on time so you don't miss your MSN to TYS flight. Be there at least two hours ahead for international flights and an hour early for domestic departures to avoid a last-minute sprint to the gate.

  • Traveling during a peak time like August? School holidays and other popular seasons can lead to longer lines and delays at airport checkpoints. Play it safe and get there up to four hours ahead of an international flight and two hours before domestic departures.

  • If you'd like to break up your flight, simply deselect 'Direct flights only' when searching for your ticket from Madison Airport to Knoxville Airport. These are the top stopovers between MSN and TYS:

    • Chicago O'Hare International Airport

    • Charlotte Douglas Airport

    • Minneapolis St Paul Airport

How to find the cheapest flights from Madison Airport (MSN) to Knoxville Airport (TYS)

  • $121 is currently the best price for a one-way Madison Airport to Knoxville Airport flight. Return flights start from $225. These prices can change based on availability and demand.

  • It's usually best to book as early as possible if you want to find cheap tickets from MSN to TYS. That's because airlines change prices based on demand, which tends to increase closer to departure.

  • If you're willing to be flexible with your travel plans, try using the 'Whole month' search function. It'll give you the lowest price in every month when searching for a flight from Madison Airport to Knoxville Airport.

  • Snapping up cheap flights from MSN to TYS couldn't be easier with Price Alerts. Simply create one of these automatic alerts and we'll get in touch when there's a better deal.

  • Tailor your flights using filters. Pick your ideal arrival and departure times, total journey duration and airlines. You can also sort your results by 'Cheapest,' 'Fastest' or 'Best' flights from Madison Airport to Knoxville Airport.

Handy information about Madison Airport (MSN)

  • MSN's address is 4000 International Lane.

  • 75% of flights that depart Madison Airport arrive at their destination on schedule.

  • Madison Airport is about 13 kilometers from central Madison. If you're driving, ride-sharing or catching a cab from the center, it'll take you 20 minutes or so to arrive, depending on the traffic.

  • Planning to take public transport? You can expect a journey time of around 40 minutes.

  • Get your vacation off to a hassle-free start by staying near MSN. Whether you're catching an early flight from Madison Airport to Knoxville Airport or just don't like being rushed, these hotels have you covered:

Arriving at Knoxville Airport (TYS)

  • The last thing you need is a long trip to your hotel if you're getting in late on a Madison Airport to Knoxville Airport flight. Book one of these accommodation options near TYS instead:

  • Grab a Knoxville Airport rental car and explore Knoxville and beyond with your own set of wheels. Budget, Alamo and Avis are well-known companies to choose from here.

  • Reserving your ride from Knoxville Airport around three weeks in advance increases your chances of getting a good deal.

Getting from Knoxville Airport (TYS) to central Knoxville

  • TYS is located at 2055 Alcoa Highway.

  • From Knoxville Airport, Knoxville is approximately 24 kilometers away. It takes around 25 minutes to get to the center driving.

  • It takes around 50 minutes if you're traveling on public transport.

When to fly to Knoxville Airport (TYS)

  • It's time to pick your dates for your flight from Madison Airport to Knoxville Airport. October is the busiest month to head to Knoxville. If you like a more relaxed vibe, go in March.

  • Before locking in your flight from Madison Airport to Knoxville Airport, think about the type of weather you like. July is the warmest month in Knoxville, with the temperature ranging from 17ºC (63ºF) to 32ºC (90ºF).

  • Look for cheap tickets from MSN to TYS in January if you'd rather travel during cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC (21ºF) and 11ºC (52ºF) on average.

Explore more of the United States

  • Columbus is just one of the many cities in the United States waiting to be discovered after you've seen Knoxville. Around 451 kilometers away to the north, its top attractions include Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theater.

  • Around 467 kilometers north-west of Knoxville, Indianapolis is another favorite stop in the United States. No visit is complete without checking out Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.