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Cheap flights from Rome to Irvine

Compare Rome to Irvine flight deals

Find the cheapest month or even day of the year to fly to Irvine

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Flight deals from Rome to Irvine

Looking for a cheap last-minute deal or the best round-trip flight from Rome to Irvine? Find the lowest prices on one-way and round-trip tickets right here.
Santa Ana.$598 per passenger.Departing Wed, Nov 11, returning Mon, Nov 16.Round-trip flight with Iberia.Outbound indirect flight with Iberia, departing from Rome Fiumicino on Wed, Nov 11, arriving in Santa Ana John Wayne.Inbound indirect flight with Iberia, departing from Santa Ana John Wayne on Mon, Nov 16, arriving in Rome Fiumicino.Price includes taxes and charges.From $598, select.
Santa Ana.$618 per passenger.Departing Thu, Aug 20, returning Sun, Aug 23.Round-trip flight with Iberia.Outbound indirect flight with Iberia, departing from Rome Fiumicino on Thu, Aug 20, arriving in Santa Ana John Wayne.Inbound indirect flight with Iberia, departing from Santa Ana John Wayne on Sun, Aug 23, arriving in Rome Fiumicino.Price includes taxes and charges.From $618, select.
Santa Ana.$685 per passenger.Departing Mon, Jul 20, returning Fri, Jul 24.Round-trip flight with United.Outbound indirect flight with United, departing from Rome Fiumicino on Mon, Jul 20, arriving in Santa Ana John Wayne.Inbound indirect flight with United, departing from Santa Ana John Wayne on Fri, Jul 24, arriving in Rome Fiumicino.Price includes taxes and charges.From $685, select.
Santa Ana.$685 per passenger.Departing Fri, Sep 25, returning Tue, Sep 29.Round-trip flight with Brussels Airlines.Outbound indirect flight with Brussels Airlines, departing from Rome Fiumicino on Fri, Sep 25, arriving in Santa Ana John Wayne.Inbound indirect flight with Brussels Airlines, departing from Santa Ana John Wayne on Tue, Sep 29, arriving in Rome Fiumicino.Price includes taxes and charges.From $685, select.
Santa Ana.$685 per passenger.Departing Fri, Jul 24, returning Sun, Aug 2.Round-trip flight with United.Outbound indirect flight with United, departing from Rome Fiumicino on Fri, Jul 24, arriving in Santa Ana John Wayne.Inbound indirect flight with United, departing from Santa Ana John Wayne on Sun, Aug 2, arriving in Rome Fiumicino.Price includes taxes and charges.From $685, select.
Santa Ana.$800 per passenger.Departing Thu, Apr 8, returning Fri, Apr 16.Round-trip flight with Scandinavian Airlines and Alaska Airlines.Outbound indirect flight with Scandinavian Airlines, departing from Rome Fiumicino on Thu, Apr 8, arriving in Santa Ana John Wayne.Inbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Fri, Apr 16, arriving in Rome Fiumicino.Price includes taxes and charges.From $800, select.
Santa Ana.$832 per passenger.Departing Fri, Mar 26, returning Wed, Mar 31.Round-trip flight with Iberia.Outbound indirect flight with Iberia, departing from Rome Fiumicino on Fri, Mar 26, arriving in Santa Ana John Wayne.Inbound indirect flight with Iberia, departing from Santa Ana John Wayne on Wed, Mar 31, arriving in Rome Fiumicino.Price includes taxes and charges.From $832, select.
Santa Ana.$857 per passenger.Departing Tue, Dec 15, returning Tue, Dec 29.Round-trip flight with Lufthansa.Outbound indirect flight with Lufthansa, departing from Rome Fiumicino on Tue, Dec 15, arriving in Santa Ana John Wayne.Inbound indirect flight with Lufthansa, departing from Santa Ana John Wayne on Tue, Dec 29, arriving in Rome Fiumicino.Price includes taxes and charges.From $857, select.
Santa Ana.$868 per passenger.Departing Fri, Aug 21, returning Sun, Sep 13.Round-trip flight with Alaska Airlines.Outbound indirect flight with Alaska Airlines, departing from Rome Fiumicino on Fri, Aug 21, arriving in Santa Ana John Wayne.Inbound indirect flight with Alaska Airlines, departing from Santa Ana John Wayne on Sun, Sep 13, arriving in Rome Fiumicino.Price includes taxes and charges.From $868, select.
Santa Ana.$874 per passenger.Departing Sun, May 2, returning Sat, May 8.Round-trip flight with Lufthansa.Outbound indirect flight with Lufthansa, departing from Rome Fiumicino on Sun, May 2, arriving in Santa Ana John Wayne.Inbound indirect flight with Lufthansa, departing from Santa Ana John Wayne on Sat, May 8, arriving in Rome Fiumicino.Price includes taxes and charges.From $874, select.
Santa Ana.$901 per passenger.Departing Mon, Oct 12, returning Thu, Oct 15.Round-trip flight with Condor.Outbound indirect flight with Condor, departing from Rome Fiumicino on Mon, Oct 12, arriving in Santa Ana John Wayne.Inbound indirect flight with Condor, departing from Santa Ana John Wayne on Thu, Oct 15, arriving in Rome Fiumicino.Price includes taxes and charges.From $901, select.
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Rome to Irvine: Flight information

The things to know before you go.
Fly intoSanta Ana John Wayne Airport
Distance to Irvine6.8 km
Cheapest flight$599
Cheapest month to flyNovember

Find the cheapest month to fly from Rome to Irvine

We always keep an eye on fares, so you can find the best flight deal in seconds. It looks like Rome to Irvine flights are currently cheapest in November. We’ve based this on flights into Santa Ana John Wayne Airport.
Jul
from $685
Aug
from $618
Sep
from $685
Oct
from $901
Nov
from $598
Dec
from $857
Jan
Find prices
Feb
Find prices
Mar
from $832
Apr
from $800
May
from $874
Jun
Find prices

Finding cheap flights from Rome to Irvine: Frequently asked questions

There are three (3) airports near Irvine: Santa Ana John Wayne Airport, Long Beach Municipal Airport, and Ontario International Airport.
The best price we found for a round-trip flight from Rome to Irvine is $598. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Rome to Irvine. But we found flights with one or more stops from $598.
We've checked every Rome to Irvine fare we could find, and the cheapest upcoming date to fly seems to be on Wednesday, November 11, 2026. Overall, the cheapest month to fly from Rome to Irvine is usually November.
If you're flying from Rome, the cheapest airport near Irvine is Santa Ana John Wayne – which is 6.8 km away from the center of Irvine. We've found flights to this airport from $598.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Rome to Irvine on Wednesday, November 11, 2026.
No airlines currently offer direct flights between Rome and Irvine. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Irvine but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Irvine is around 40 days in advance, so don’t leave your flight to the last minute.

Santa Ana John Wayne Airport is 6.8km from Irvine, Long Beach Municipal Airport is 36.2km from Irvine, and Ontario International Airport is 44.9km from Irvine.
Santa Ana John Wayne Airport is closest to Irvine, at around 6.8 km away.
The cheapest airline that flies to Irvine is Iberia.