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Cheap flights from Santo Domingo to Medellin

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Flight deals from Santo Domingo to Medellin

Looking for a cheap last-minute deal or the best round-trip flight from Santo Domingo to Medellin? If you want to travel next month, round-trip fares start from $252. Find the lowest prices on one-way and round-trip tickets right here.
Medellin.$252 per passenger.Departing Sun, Sep 27, returning Wed, Sep 30.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Sun, Sep 27, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Wed, Sep 30, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $252, select.
Medellin.$252 per passenger.Departing Sat, Aug 15, returning Sat, Aug 22.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Sat, Aug 15, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Sat, Aug 22, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $252, select.
Medellin.$252 per passenger.Departing Sat, Aug 22, returning Tue, Sep 1.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Sat, Aug 22, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Tue, Sep 1, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $252, select.
Medellin.$252 per passenger.Departing Tue, Nov 10, returning Tue, Nov 17.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Tue, Nov 10, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Tue, Nov 17, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $252, select.
Medellin.$253 per passenger.Departing Sat, Oct 24, returning Tue, Nov 3.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Sat, Oct 24, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Tue, Nov 3, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $253, select.
Medellin.$255 per passenger.Departing Tue, Oct 6, returning Sun, Oct 11.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Tue, Oct 6, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Sun, Oct 11, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $255, select.
Medellin.$256 per passenger.Departing Tue, Dec 1, returning Fri, Dec 11.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Tue, Dec 1, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Fri, Dec 11, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $256, select.
Medellin.$260 per passenger.Departing Wed, Jul 15, returning Wed, Jul 22.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Wed, Jul 15, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Wed, Jul 22, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $260, select.
Medellin.$261 per passenger.Departing Wed, Sep 30, returning Sat, Oct 10.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Wed, Sep 30, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Sat, Oct 10, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $261, select.
Medellin.$262 per passenger.Departing Mon, Sep 7, returning Sat, Nov 7.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Mon, Sep 7, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Sat, Nov 7, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $262, select.
Medellin.$262 per passenger.Departing Wed, Jul 29, returning Fri, Aug 7.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Wed, Jul 29, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Fri, Aug 7, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $262, select.
Medellin.$265 per passenger.Departing Tue, Nov 24, returning Tue, Dec 1.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Tue, Nov 24, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Tue, Dec 1, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $265, select.
Medellin.$268 per passenger.Departing Sat, Feb 6, returning Sat, Feb 20.Round-trip flight with Wingo.Outbound direct flight with Wingo departing from Santo Domingo Las Americas on Sat, Feb 6, arriving in José María Córdova International.Inbound direct flight with Wingo departing from José María Córdova International on Sat, Feb 20, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $268, select.
Medellin.$274 per passenger.Departing Tue, Jan 12, returning Tue, Jan 19.Round-trip flight with Wingo.Outbound direct flight with Wingo departing from Santo Domingo Las Americas on Tue, Jan 12, arriving in José María Córdova International.Inbound direct flight with Wingo departing from José María Córdova International on Tue, Jan 19, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $274, select.
Medellin.$278 per passenger.Departing Fri, Jan 29, returning Fri, Feb 5.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Fri, Jan 29, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Fri, Feb 5, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $278, select.
Medellin.$279 per passenger.Departing Tue, Dec 1, returning Tue, Jan 12.Round-trip flight with Arajet.Outbound direct flight with Arajet departing from Santo Domingo Las Americas on Tue, Dec 1, arriving in José María Córdova International.Inbound direct flight with Arajet departing from José María Córdova International on Tue, Jan 12, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $279, select.

Find the cheapest month to fly from Santo Domingo to Medellin

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santo Domingo to Medellin flights are currently cheapest in August.
Jul
from $260
Aug
from $252
Sep
from $252
Oct
from $255
Nov
from $252
Dec
from $256
Jan
from $273
Feb
from $268
Mar
from $288
Apr
from $353
May
from $336
Jun
from $361

Direct flights from Santo Domingo to Medellin

Alternative Santo Domingo to Medellin routes

Looking for the cheapest, fastest or easiest route from Santo Domingo to Medellin? You could fly into the following airports instead.

Medellin Enrique Olaya Herrera

3km from central Medellin
Closest
from $388
Search flights

José María Córdova International

19km from central Medellin
Cheapest
from $252
Search flights

Santo Domingo to Medellin: Flight information

The things to know before you go.
Cheapest flight found$252
Cheapest month to flyAugust
Average flight time2 hrs, 32 mins
Most popular airlineArajet
Average flights per week30

Finding cheap flights from Santo Domingo to Medellin: Frequently asked questions

There are 2 airports in Medellin: Medellin Enrique Olaya Herrera and José María Córdova International.
The best price we found for a round-trip flight from Santo Domingo to Medellin is $252. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 32 minutes is the average flight time from Santo Domingo to Medellin.
Arajet, World Ticket Ltd and Copa Airlines Colombia fly direct from Santo Domingo to Medellin.
There are 30 flights per week flying from Santo Domingo to Medellin, as of July 2026.
The cheapest month to fly from Santo Domingo to Medellin is usually August.
If you're flying from Santo Domingo, the cheapest airport near Medellin is José María Córdova International – which is 18.9 km away from the center of Medellin. We've found flights to this airport from $252.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santo Domingo to Medellin on Saturday, August 15, 2026.
Yes – the average flight time is 2 hours and 32 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Medellin but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Medellin is around 40 days in advance, so don’t leave your flight to the last minute.

In July, the average temperature is usually around 18°C. May is typically the warmest month in Medellin, when it usually averages around 21°C. You can expect the least rain in January. The coldest month is November, with temperatures averaging 15°C. The rainiest month is May.
The cheapest airline that flies to Medellin is Arajet.

Traveling from Santo Domingo to Medellin: what you need to know

  • Start your travel planning by considering where you'll take off for your flight from Santo Domingo to Medellin. Santo Domingo Las Americas Airport (SDQ) and La Isabela International Airport (JBQ) are Santo Domingo's main airports.

  • Medellin Jose Maria Cordova Airport (MDE) is the primary point of entry to Medellin.

  • Around 2 hours 30 minutes is how long you can expect to be in the air on a direct Santo Domingo to Medellin flight.

  • Medellin's timezone is UTC-5, making Medellin one hour behind Santo Domingo.

  • The busiest route for flights from Santo Domingo to Medellin is from Santo Domingo Las Americas Airport (SDQ) to Medellin Jose Maria Cordova Airport (MDE). You can select from 11 services every week between these two airports. If you want to maximize your time on arrival, the earliest flight from SDQ to MDE is the 06:00 Arajet option. If you have other commitments or plans on your day of travel, the last departure is at 19:10 with Arajet.

  • To ensure you make your Santo Domingo to Medellin flight, leave plenty of time to check in and find your gate. Arriving two hours before international departures and one hour before domestic flights is a good rule of thumb.

  • Be prepared for longer lines in popular months such as July. Arriving up to four hours ahead of international flights and two hours for domestic departures is a wise move.

How to find the cheapest flights from Santo Domingo to Medellin

  • Booking early is often the key to finding a cheap Santo Domingo to Medellin flight. Fares tend to rise as seats fill up, so the nearer your departure date, the more you'll likely spend on your ticket.

  • If you're willing to be flexible with your travel plans, use the 'Whole month' search tool. It'll show you the lowest price in every month when looking for your plane ticket from Santo Domingo to Medellin.

  • Locking in a cheap flight from Santo Domingo to Medellin is a breeze with Price Alerts. All you need to do is set up one of these automatic alerts and we'll let you know as soon as there's a better deal.

  • Find an affordable Santo Domingo to Medellin flight with the help of our filters. Select your ideal departure time, duration and airlines, then sort the results by 'Cheapest' for the best deals.

Flying from Santo Domingo

Santo Domingo Las Americas Airport (SDQ)

  • Jet off from Santo Domingo Las Americas Airport (SDQ) on a nonstop flight from Santo Domingo to Medellin. From SDQ, you can fly directly into Medellin Jose Maria Cordova Airport (MDE).

  • Check out the deals with Arajet. This airline offers direct Santo Domingo to Medellin plane tickets out of SDQ.

  • A stopover is the ideal opportunity to take a travel break — and maybe even explore another city. When searching for Santo Domingo to Medellin flights departing from Santo Domingo Las Americas Airport, deselect the 'Direct flights only' box to see where you can visit along the way. Here are some options to consider:

    • Bogota Airport (BOG)

    • Cartagena Airport (CTG)

    • Caracas Airport (CCS)

  • Located around 24 kilometers from the center of Santo Domingo, SDQ can be reached in about 35 minutes by car, depending on traffic. The journey on public transport will take roughly 1 hour 15 minutes.

  • After a relaxed start to your break? Stay near Santo Domingo Las Americas Airport. Whether you have an early flight from Santo Domingo to Medellin or just don't want to be rushed, these hotels are the answer:

  • 76% of flights that take off from Santo Domingo Las Americas Airport touch down at their destination on schedule.

Arriving in Medellin

Medellin Jose Maria Cordova Airport (MDE)

  • Medellin Jose Maria Cordova Airport (MDE) is approximately 18 kilometers from central Medellin. If you're catching a cab or a ride-share, the drive will take around 45 minutes.

  • If you're taking public transport, expect a journey time of roughly 1 hour 15 minutes.

  • If you're coming in on a late flight from Santo Domingo to Medellin, few things beat the convenience of staying close to the terminal. Grab your bags from the carousel and then be showered and relaxing not long after at one of these accommodation options near MDE:

  • Go wherever you want, whenever you want with a Medellin Jose Maria Cordova Airport rental car. Pick up a set of wheels from Localiza, Green Motion or Confort Rent a Car and see more of Medellin and beyond.

  • To lock in the lowest price, reserve your vehicle from Medellin Jose Maria Cordova Airport around one week in advance of your Santo Domingo to Medellin flight.

Medellin Enrique Olaya Herrera Airport (EOH)

  • The center of Medellin is about 3 kilometers from Medellin Enrique Olaya Herrera Airport (EOH). Once your flight from Santo Domingo to Medellin has touched down and you've made your way to arrivals, expect a drive of about 15 minutes.

  • You can expect the trip to take roughly 25 minutes on public transport.

  • Hang up the 'Do not disturb' sign and relax at a hotel close to EOH. Here are a few options where you can check in after your flight from Santo Domingo to Medellin:

  • Why wait? A Medellin Enrique Olaya Herrera Airport rental car lets you start your journey right away. Crank up the music and hit the highway with a set of wheels from Confort Rent a Car or Green Motion.

  • Get exactly what you want. Securing your ride from EOH one week in advance often means more savings and a wider selection of vehicles.

Best time to go to Medellin

  • March is the quietest month for flights from Santo Domingo to Medellin, while December is the busiest. Choose the ideal time to visit Medellin based on whether you want a laid-back vibe or a more bustling atmosphere.

  • Before locking in your Santo Domingo to Medellin tickets, consider the kind of weather forecast you're hoping for. August is the warmest month in Medellin, with temperatures ranging from 9ºC (48ºF) to 27ºC (81ºF).

  • December has average temperatures of between 9ºC (48ºF) and 24ºC (75ºF). Look for cheap flights from Santo Domingo to Medellin around that time if you'd rather travel in cooler conditions.

More about Medellin

  • When it comes to searching for somewhere to lay your head, you'll find the most popular stays in Medellin right here. Check out these options after you've booked your flight from Santo Domingo to Medellin:

  • Palacio de Bellas Artes and Museo comuna 13 are a couple of top-rated attractions to put on your Medellin must-do list. Keep the sightseeing going at Laguna de Guatape.

Explore more of Colombia

  • Medellin has plenty going for it, but there are so many other parts of Colombia you should also see. Around 241 kilometers southeast of Medellin, a trip to Bogota will keep you on the move. Start with popular sights like Teatro Colon Bogota, Gold Museum and Museum of Contemporary Art of Bogota.

  • Around 322 kilometers south of Medellin, Cali is another favorite stop in Colombia. Get a taste of what this destination has to offer at Cristo Rey, Parque Simón Bolívar and San Felipe Lodge. Birding & Wellness RN.

More travel options

Plan the rest of your trip from Santo Domingo to Medellin

Prices shown on this page are estimated lowest prices only. Found in the last 12 days.