Cheap flights from Santa Ana John Wayne to Panama City

Compare Santa Ana John Wayne to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from Santa Ana John Wayne to Panama City

Looking for a cheap last-minute deal or the best round-trip flight from Santa Ana John Wayne Airport to Panama City? If you want to travel next month, round-trip fares start from $836. Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from Santa Ana John Wayne to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santa Ana John Wayne to Panama City flights are currently cheapest in October.

Alternative Santa Ana John Wayne to Panama City routes

Looking for the cheapest, fastest or easiest route from Santa Ana John Wayne to Panama City? You could fly into the following airports instead.

Santa Ana to Panama City: Flight information

The things to know before you go.
Cheapest flight found$721
Cheapest month to flyOctober

Finding cheap flights from Santa Ana John Wayne to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a round-trip flight from Santa Ana John Wayne to Panama City is $721. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Santa Ana John Wayne to Panama City. But we found flights with one or more stops from $721.
There are no flights flying from Santa Ana John Wayne to Panama City, as of May 2026.
The cheapest month to fly from Santa Ana John Wayne to Panama City is usually October.
If you're flying from Santa Ana John Wayne Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the center of Panama City. We've found flights to this airport from $721.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Santa Ana John Wayne Airport to Panama City on Wednesday, October 21, 2026.
No airlines currently offer direct flights between Santa Ana John Wayne Airport and Panama City. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In May, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
Currently, United offers the cheapest flight tickets to Panama City.

Flying from John Wayne Airport (SNA) to Panama City: what you need to know

  • The timezone in Panama City is UTC-5. The city is two hours ahead of Santa Ana, where John Wayne Airport is located.

  • To avoid rushing for your SNA to Panama City flight, leave plenty of time for things like check-in and baggage drop. Arriving two hours ahead of international departures and an hour before domestic flights is the standard rule.

  • If you're flying during a public holiday or another peak period, allow for even more time. A good general rule is two hours before domestic flights and up to four hours before international departures. Queues at check-in and security will be longer.

  • Stopovers are the perfect opportunity to break up your journey and possibly even explore a different city. When browsing for flight tickets from SNA to Panama City, uncheck the 'Direct flights only' box to see where you can visit along the way. Some popular options include:

    • Denver International Airport (DEN)

    • George Bush Intercontinental Airport (IAH)

    • Austin-Bergstrom International Airport (AUS)

  • SNA is around 8 kilometers from central Santa Ana. If you're ride-sharing, driving or catching a cab from the center, it'll take 15 minutes or so to get there, depending on traffic. If you're planning to take public transport, expect the journey time to be around 1 hour 5 minutes.

  • Want a hassle-free start to your trip? Stay near SNA. Whether you've booked an early flight from John Wayne Airport to Panama City or don't want departure day to feel hectic, these hotels have you covered:

  • John Wayne Airport maintains a strong on-time record, reducing the likelihood of delays. Departures from SNA touch down on schedule 81.53% of the time.

  • You'll find SNA at 18601 Airport Way.

How to find the cheapest flights from John Wayne Airport (SNA) to Panama City

  • $383 is the lowest price we've found for a one-way John Wayne Airport to Panama City flight. A return ticket right now is $721. Depending on how early you book and the availability, these fares can change.

  • Booking in advance is often the key to locking in a cheap flight from SNA to Panama City. Flight prices rise as demand increases, so the nearer your departure date, the more it could cost you.

  • The 'Whole month' tool will show you the cheapest tickets from John Wayne Airport to Panama City throughout the entire month. It's a great way to snap up a bargain if your dates are flexible.

  • Never miss a deal on cheap flights from SNA to Panama City by creating a Price Alert. You'll receive an email or push notification on the app when a new discounted fare appears.

  • Pick your preferred arrival and departure times, airlines and number of stops with our filters. Then, sort the results for your flight from John Wayne Airport to Panama City by 'Best,' 'Cheapest' or 'Fastest.'

Airports in Panama City

Tocumen International Airport (PTY)

  • Tocumen International Airport (PTY) to the center of Panama City takes around 20 minutes to reach by car. The center is roughly 21 kilometers away.

  • It takes around 1 hour 5 minutes if you're traveling on public transport.

  • The last thing you want is a long journey to your hotel if you're arriving on a late flight from John Wayne Airport to Panama City. Stay at one of these accommodation options near PTY instead:

  • Grab a Tocumen International Airport rental car and explore Panama City and beyond with your own wheels. Avis, Dollar and MEX are top outlets to choose from here.

  • Booking your vehicle from Tocumen International Airport around three weeks before your flight from SNA to Panama City can help you secure the lowest rate.

Marcos A. Gelabert International Airport (PAC)

  • Once your flight from John Wayne Airport to Panama City has hit the tarmac, you can get to the city center in around 5 minutes by car. Central Panama City is roughly 2 kilometers from Marcos A. Gelabert International Airport (PAC).

  • If you travel by public transport, the journey will take you 25 minutes or so.

  • There are some great places to call home for the night near PAC. Tuck yourself in and get cozy after your SNA to Panama City flight at one of these well-located options:

  • The fastest way to reach your destination is with a Marcos A. Gelabert International Airport rental car. Grab your wheels from Thrifty, Avis or Alamo and hit the road in a heartbeat.

  • Avoid paying extra. Booking your ride three weeks before your arrival at PAC will help you save.

Panama Pacifico Airport (BLB)

  • Panama Pacifico Airport (BLB) is about 16 kilometers from central Panama City. It'll take you about 20 minutes to reach the city center in a ride-share or cab after your flight from John Wayne Airport to Panama City.

  • Stay at a hotel close to BLB and get from baggage claim to your bed in a snap. Whether you have a late SNA to Panama City flight or just want an easier arrival, these stays bring comfort closer to you:

  • Whether you want an economy for a solo trip or an SUV to transport your group, you'll find the ideal Panama Pacifico Airport rental car for your needs. Explore the types of wheels available here from suppliers such as Sixt, Dollar and Thrifty.

  • If you're looking for a specific make or model, book your ride from BLB around one week before your flight from John Wayne Airport to Panama City. This gives you a higher chance of getting your preferred car, along with a better deal.

Best time to go to Panama City

  • Travel to Panama City in high season if you like a lively atmosphere, but remember that prices tend to be higher. Alternatively, book flights from John Wayne Airport to Panama City during low season when prices are cheaper and it's quieter.

  • Lock in a John Wayne Airport to Panama City flight ticket with a departure in March if you want to experience the city during its warmest month. You can expect temperatures to range from 21ºC (70ºF) to 32ºC (90ºF).

  • Search for cheap tickets from SNA to Panama City in February if you want to travel in cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

  • After booking your flight from John Wayne Airport to Panama City, find a hotel that offers the right mix of comfort and location. Make one of these options your base for exploring Panama City:

  • Every great vacation has to include a little sightseeing. Casco Viejo, Panama Canal Museum and Cinta Costera are must-visits when exploring Panama City.

Explore more of Panama

  • David is just one of the many places in Panama waiting to be explored once you've seen Panama City. Around 322 kilometers away to the west, top sights here include Parque Cervantes, Altos del Rio Park and Coquito Hills Park.

  • Santiago de Veraguas is another essential stop in Panama and is around 193 kilometers south-west of Panama City. No trip is complete without a visit to Santiago the Apostle Cathedral, Santiago de Veraguas, The Church of Jesus Christ of Latter Day Saints and La Placita San Juan De Dios.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.