Cheap flights from St Louis to Knoxville

Compare St Louis to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

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Flight deals from St Louis to Knoxville

Looking for a cheap last-minute deal or the best round-trip flight from St Louis Airport to Knoxville Airport? If you want to travel next month, round-trip fares start from $248. Find the lowest prices on one-way and round-trip tickets right here.

Find the cheapest month to fly from St Louis to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like St Louis to Knoxville flights are currently cheapest in August.

St Louis to Knoxville: Alternative routes

Compare routes from St Louis to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

St Louis to Knoxville: Flight information

The things to know before you go.
Cheapest flight found$218
Cheapest month to flyAugust

Finding cheap flights from St Louis to Knoxville: Frequently asked questions

The best price we found for a round-trip flight from St Louis to Knoxville is $218. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from St Louis to Knoxville. But we found flights with one or more stops from $218.
There are no flights flying from St Louis to Knoxville, as of May 2026.
The cheapest month to fly from St Louis to Knoxville is usually August.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from St Louis Airport to Knoxville Airport on Thursday, August 27, 2026.
No airlines currently offer direct flights between St Louis Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Frontier Airlines offers the cheapest flight tickets to Knoxville.

Traveling from Lambert-St. Louis International Airport (STL) to McGhee Tyson Airport (TYS): what you need to know

  • Arriving two hours before an international flight and one hour ahead of a domestic departure are travel rules to live by. Be at the airport with enough time to catch your STL to TYS flight.

  • Traveling during a peak time like July? Public holidays and other high seasons can result in longer queues at check-in and security. Be extra cautious and get there up to four hours ahead of an international flight and two hours before domestic departures.

  • We make it easy to book a flight with a stopover. To see all your options for tickets from Lambert-St. Louis International Airport to McGhee Tyson Airport, uncheck 'Direct flights only.' Then, pick a flight offering a stop long enough to visit the city of your choice. Popular stopovers between STL and TYS include:

    • Hartsfield-Jackson Atlanta International Airport

    • Chicago Midway International Airport

    • Detroit Metropolitan Wayne County Airport

How to find the cheapest flights from Lambert-St. Louis International Airport (STL) to McGhee Tyson Airport (TYS)

  • $100 is the best price for a one-way Lambert-St. Louis International Airport to McGhee Tyson Airport flight. Return flights start from $218. These fares may change depending on demand and availability.

  • To get your hands on cheap tickets from STL to TYS, book ahead. Airlines tend to offer the most competitive fares when flights are first released.

  • If you're willing to be flexible with your travel dates, use the 'Whole month' tool. It'll find the lowest price across the month when searching for a flight from Lambert-St. Louis International Airport to McGhee Tyson Airport.

  • Picking up cheap flights from STL to TYS is a breeze with Price Alerts. All you need to do is create one of these automatic alerts and we'll notify you as soon as fares go down.

  • Choose your preferred departure and arrival times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to get the best deals on flights from Lambert-St. Louis International Airport to McGhee Tyson Airport.

Handy information about Lambert-St. Louis International Airport (STL)

  • You'll find STL at 10701 Lambert International Blvd..

  • When it comes to Lambert-St. Louis International Airport's on-time performance, data shows 78.04% of flights arrive within the scheduled timeframe.

  • To reach Lambert-St. Louis International Airport from central St Louis, it'll take around 20 minutes if you're going by car. Of course, this depends on traffic. It's approximately 26 kilometers from the airport to the city center.

  • Planning to catch public transport? You can expect a journey time of around 35 minutes.

  • Get your travels off to a relaxed start by staying near STL. Whether you're catching an early flight from Lambert-St. Louis International Airport to McGhee Tyson Airport or want to avoid feeling rushed, these hotels have you covered:

Arriving at McGhee Tyson Airport (TYS)

  • Reserve a hotel close to TYS if you're taking a late Lambert-St. Louis International Airport to McGhee Tyson Airport flight. Select one of these options and skip the long transfer after landing:

  • Go wherever you want, whenever you want with a McGhee Tyson Airport rental car. Book your wheels from Budget, Alamo or Avis and discover more of Knoxville and beyond.

  • Reserving your vehicle from McGhee Tyson Airport about three weeks in advance increases your chances of getting a good deal.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • The street address for TYS is 2055 Alcoa Highway.

  • McGhee Tyson Airport to the center of Knoxville has a drive time of around 20 minutes. It's approximately 23 kilometers away.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from Lambert-St. Louis International Airport to McGhee Tyson Airport is February, while July is the busiest. Pick the best time to visit Knoxville based on whether you prefer a more fast-paced or easygoing experience.

  • When reserving your flight from Lambert-St. Louis International Airport to McGhee Tyson Airport, consider the type of weather you like. July is the warmest month in Knoxville, with temperatures ranging from 17ºC (63ºF) to 32ºC (90ºF).

  • Search for cheap tickets from STL to TYS in January if you like cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC (21ºF) and 11ºC (52ºF) on average.

Explore more of United States

  • Columbus is just one of the many places in United States waiting to be discovered after you've experienced Knoxville. Around 451 kilometers away to the north, check out popular attractions including Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • Around 467 kilometers north-west of Knoxville, Indianapolis is another favorite stop in United States. Experience major highlights starting with The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.