Cheap flights from Madrid to Panama City

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Flight deals from Madrid to Panama City

Looking for a cheap last-minute deal or the best round-trip flight from Madrid Airport to Panama City? If you want to travel next month, round-trip fares start from $848. Find the lowest prices on one-way and round-trip tickets right here.

Panama City.$644 per passenger.Departing Sat, Sep 19, returning Mon, Oct 19.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Sat, Sep 19, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Mon, Oct 19, arriving in Madrid.Price includes taxes and charges.From $644, select.

Panama City.$644 per passenger.Departing Fri, Sep 11, returning Sun, Sep 27.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Fri, Sep 11, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Sun, Sep 27, arriving in Madrid.Price includes taxes and charges.From $644, select.

Panama City.$644 per passenger.Departing Fri, Sep 11, returning Sun, Nov 22.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Fri, Sep 11, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Sun, Nov 22, arriving in Madrid.Price includes taxes and charges.From $644, select.

Panama City.$656 per passenger.Departing Sun, Aug 23, returning Wed, Oct 21.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Sun, Aug 23, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Wed, Oct 21, arriving in Madrid.Price includes taxes and charges.From $656, select.

Panama City.$687 per passenger.Departing Fri, Oct 23, returning Fri, Nov 6.Round-trip flight with United.Outbound indirect flight with United, departing from Madrid on Fri, Oct 23, arriving in Panama City Tocumen International.Inbound indirect flight with United, departing from Panama City Tocumen International on Fri, Nov 6, arriving in Madrid.Price includes taxes and charges.From $687, select.

Panama City.$690 per passenger.Departing Sun, Aug 23, returning Thu, Sep 24.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Sun, Aug 23, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Thu, Sep 24, arriving in Madrid.Price includes taxes and charges.From $690, select.

Panama City.$692 per passenger.Departing Thu, Oct 15, returning Tue, Oct 20.Round-trip flight with United.Outbound indirect flight with United, departing from Madrid on Thu, Oct 15, arriving in Panama City Tocumen International.Inbound indirect flight with United, departing from Panama City Tocumen International on Tue, Oct 20, arriving in Madrid.Price includes taxes and charges.From $692, select.

Panama City.$694 per passenger.Departing Wed, Oct 21, returning Wed, Dec 9.Round-trip flight with United.Outbound indirect flight with United, departing from Madrid on Wed, Oct 21, arriving in Panama City Tocumen International.Inbound indirect flight with United, departing from Panama City Tocumen International on Wed, Dec 9, arriving in Madrid.Price includes taxes and charges.From $694, select.

Panama City.$695 per passenger.Departing Tue, Aug 25, returning Mon, May 31.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Tue, Aug 25, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Mon, May 31, arriving in Madrid.Price includes taxes and charges.From $695, select.

Panama City.$697 per passenger.Departing Fri, Nov 13, returning Mon, Nov 16.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Fri, Nov 13, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Mon, Nov 16, arriving in Madrid.Price includes taxes and charges.From $697, select.

Panama City.$711 per passenger.Departing Sun, Feb 7, returning Sun, Feb 14.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Sun, Feb 7, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Sun, Feb 14, arriving in Madrid.Price includes taxes and charges.From $711, select.

Panama City.$713 per passenger.Departing Mon, Feb 22, returning Thu, Apr 15.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Mon, Feb 22, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Thu, Apr 15, arriving in Madrid.Price includes taxes and charges.From $713, select.

Panama City.$713 per passenger.Departing Thu, Jun 3, returning Thu, Jun 24.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Thu, Jun 3, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Thu, Jun 24, arriving in Madrid.Price includes taxes and charges.From $713, select.

Panama City.$713 per passenger.Departing Wed, Jan 20, returning Tue, Feb 2.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Wed, Jan 20, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Tue, Feb 2, arriving in Madrid.Price includes taxes and charges.From $713, select.

Panama City.$713 per passenger.Departing Wed, Mar 17, returning Sat, Apr 3.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Wed, Mar 17, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Sat, Apr 3, arriving in Madrid.Price includes taxes and charges.From $713, select.

Panama City.$713 per passenger.Departing Fri, Feb 12, returning Fri, Mar 5.Round-trip flight with Avianca.Outbound indirect flight with Avianca, departing from Madrid on Fri, Feb 12, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departing from Panama City Tocumen International on Fri, Mar 5, arriving in Madrid.Price includes taxes and charges.From $713, select.

Find the cheapest month to fly from Madrid to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Madrid to Panama City flights are currently cheapest in September.

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Direct flights from Madrid to Panama City

Alternative Madrid to Panama City routes

Looking for the cheapest, fastest or easiest route from Madrid to Panama City? You could fly into the following airports instead.

Madrid to Panama City: Flight information

The things to know before you go.

Cheapest flight found	$644
Cheapest month to fly	September
Average flight time	10 hrs, 47 mins
Most popular airline	Copa
Average flights per week	112

Finding cheap flights from Madrid to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are round-trip flights from Madrid to Panama City?

The best price we found for a round-trip flight from Madrid to Panama City is $644. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Madrid to Panama City?

10 hours and 47 minutes is the average flight time from Madrid to Panama City.

Which airlines fly direct from Madrid to Panama City?

Copa, Etihad Airways and Air Europa fly direct from Madrid to Panama City.

How many flights are there a week from Madrid to Panama City?

There are 56 flights per week flying from Madrid to Panama City, as of July 2026.

When is the cheapest time to fly from Madrid to Panama City?

The cheapest month to fly from Madrid to Panama City is usually September.

What's the cheapest airport to fly to in Panama City?

If you're flying from Madrid Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the center of Panama City. We've found flights to this airport from $644.

Which upcoming date is cheapest to fly from Madrid Airport to Panama City on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Madrid Airport to Panama City on Friday, September 11, 2026.

Can I get a direct flight from Madrid Airport to Panama City?

Yes – the average flight time is 10 hours and 47 minutes.

How can I get the best flight deal from Madrid Airport to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar, and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In July, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly with from Madrid Airport to Panama City?

Currently, Avianca and Air Europa offer the cheapest flight tickets to Panama City.

Traveling from Adolfo Suarez Madrid-Barajas Airport (MAD) to Panama City: what you need to know

Approximately 9 hours 50 minutes is how long you'll be traveling on a direct flight from Adolfo Suarez Madrid-Barajas Airport to Panama City.
Panama City is six hours behind Madrid, where Adolfo Suarez Madrid-Barajas Airport is located. Panama City follows the UTC-5 timezone.
With ten weekly flights between the two airports, Adolfo Suarez Madrid-Barajas Airport (MAD) to Panama City Tocumen International Airport (PTY) is the busiest route. Catch Iberia's 11:45 flight to get your trip from MAD to PTY underway.
For a relaxed start to your MAD to Panama City flight, leave plenty of time for things like baggage drop and finding your gate. Arriving two hours ahead of international departures and an hour before domestic flights is the standard rule.
During popular months such as July, you'll want to get to the airport earlier than usual. Arrive two hours before domestic departures and four hours ahead of an international flight when you travel during high season in general.
Begin your journey at MAD and travel nonstop to Panama City Tocumen International Airport (PTY). That will be your arrival point when searching for Adolfo Suarez Madrid-Barajas Airport to Panama City tickets.
Air Europa is a well-known carrier that offers direct flights from Adolfo Suarez Madrid-Barajas Airport to Panama City.
Think about adding a stopover to potentially unlock a cheaper plane ticket from MAD to Panama City. All you need to do is deselect 'Direct flights only' during your search. Take a detour (and maybe pocket some savings) by stopping at one of these popular airports:
- Miami International Airport (MIA)
- Bogota El Dorado International Airport (BOG)
- Medellin Jose Maria Cordova Intl Airport (MDE)
Located around 13 kilometers from the center of Madrid, MAD can be reached in about 20 minutes by car, depending on traffic. Traveling on public transport will take roughly 30 minutes.
Want a hassle-free start to your trip? Stay near MAD. Whether you're catching an early flight from Adolfo Suarez Madrid-Barajas Airport to Panama City or just don't like being rushed, these hotels are just the thing:
Of the departures from Adolfo Suarez Madrid-Barajas Airport, 77% touch down on time at their destination.

How to find the cheapest flights from Adolfo Suarez Madrid-Barajas Airport (MAD) to Panama City

The lowest price we've found for a one-way Adolfo Suarez Madrid-Barajas Airport to Panama City flight is $316. The cheapest price for a return flight is $644. Remember fares can change due to demand at the time of booking.
Book 11 months before flying. Pricing trends show that this is the ideal window for finding cheap flights from MAD to Panama City.
April is the best month for picking up a fantastic deal on Adolfo Suarez Madrid-Barajas Airport to Panama City tickets. If you need to travel during a different time of year, the 'Whole month' tool will give you the lowest prices across every month.
Snapping up a cheap flight from MAD to Panama City is easy with Price Alerts. Simply create one of these automatic notifications and we'll notify you as soon as a better deal is available.
Select your ideal arrival and departure times, number of stops and airlines with our filters. Then, sort the results for your flight from Adolfo Suarez Madrid-Barajas Airport to Panama City by 'Cheapest,' 'Best' or 'Fastest.'

Airports in Panama City

Panama City Tocumen International Airport (PTY)

Panama City Tocumen International Airport (PTY) to central Panama City takes about 35 minutes to reach by car. The center is roughly 24 kilometers away.
Getting there by public transport takes around 50 minutes.
Look into staying at a hotel near PTY if you have a late flight from Adolfo Suarez Madrid-Barajas Airport to Panama City. Settle into one of these options and avoid the hassle of a long transfer:
Booking your vehicle from Panama City Tocumen International Airport around three weeks in advance of your flight from MAD to Panama City can help you get the best possible rate.

Panama Pacifico International Airport (BLB)

Panama Pacifico International Airport (BLB) is around 6 kilometers from central Panama City. After your flight from Adolfo Suarez Madrid-Barajas Airport to Panama City, it'll take you around 10 minutes to get to the heart of the city in a ride-share or cab.
The trip will take about 20 minutes on public transport.
Hang up the 'Do not disturb' sign and rest at a hotel close to BLB. Here are a few options where you can check in after your MAD to Panama City flight:
Lock in the lowest price by booking your ride from BLB one week in advance. You can also expect to have a greater selection of vehicles.

Best time to go to Panama City

September is the quietest month for flights from Adolfo Suarez Madrid-Barajas Airport to Panama City, while January is the busiest. Figure out the best time to visit Panama City based on whether you want a bustling atmosphere or a more laid-back vibe.
Lock in a Adolfo Suarez Madrid-Barajas Airport to Panama City plane ticket with a departure in March to visit the city during its warmest month. Expect temperatures to range from 21ºC (70ºF) to 32ºC (90ºF).
Look for cheap tickets from MAD to Panama City in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC (72ºF) and 31ºC (88ºF) on average.

More about Panama City

Start your Panama City trip right by choosing the ideal place to stay. As soon as you've booked your flight from Adolfo Suarez Madrid-Barajas Airport to Panama City, explore our selection of hotels including:
All great vacations should include a little sightseeing. Metropolitan Cathedral (Catedral Metropolitan), Casco Viejo and Independence Square are essential stops on your Panama City itinerary.

Explore more of Panama

David is just one of the many cities in Panama waiting to be explored after you've experienced Panama City. Around 322 kilometers away to the west, well-known attractions include Museo Antropológico y Etnográfico Dr. Roberto De La Guardia, Raptors To The Rescue and Unachi Botanical garden.
Next up? Make your way to Santiago de Veraguas. It's located about 193 kilometers southwest of Panama City and home to highlights like Santiago the Apostle Cathedral, Santiago de Veraguas.